Assay Detail
Binding
CHEMBL4026879
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Design and Discovery of New M2 Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 5.39 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4069313 | — | — | 1 | 8.31 |
| CHEMBL4100938 | — | — | 1 | 6.85 |
| CHEMBL4065555 | — | — | 1 | 6.64 |
| CHEMBL667 | ACETYLCHOLINE | 4.0 | 1 | 6.41 |
| CHEMBL4081662 | — | — | 1 | 6.20 |
| CHEMBL4093215 | — | — | 1 | 6.10 |
| CHEMBL4085150 | — | — | 1 | 6.03 |
| CHEMBL4064668 | — | — | 1 | 6.01 |
| CHEMBL4073256 | — | — | 1 | 6.00 |
| CHEMBL4075227 | — | — | 1 | 5.92 |
| CHEMBL4103375 | — | — | 1 | 5.89 |
| CHEMBL4102555 | — | — | 1 | 5.62 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 5.39 |
| CHEMBL4103087 | — | — | 1 | 5.38 |
| CHEMBL4085451 | — | — | 1 | 5.36 |
| CHEMBL4094819 | — | — | 1 | 5.32 |
| CHEMBL4071109 | — | — | 1 | 5.24 |
| CHEMBL4072787 | — | — | 1 | 5.22 |
| CHEMBL4070055 | — | — | 1 | 5.20 |
| CHEMBL4089027 | — | — | 1 | 5.04 |
| CHEMBL4061390 | — | — | 1 | 5.00 |
| CHEMBL4099673 | — | — | 1 | 4.96 |
| CHEMBL4060823 | — | — | 1 | 4.89 |
| CHEMBL4095626 | — | — | 1 | 4.85 |
| CHEMBL4092348 | — | — | 1 | 4.85 |
| CHEMBL4091934 | — | — | 1 | 4.85 |
| CHEMBL4061384 | — | — | 1 | 4.82 |
| CHEMBL4083241 | — | — | 1 | 4.77 |
| CHEMBL4099667 | — | — | 1 | 4.66 |
| CHEMBL4097248 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4069313 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL4100938 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL4065555 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL667 | ACETYLCHOLINE | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL4081662 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL4093215 | — | Ki | = | 790.0 | nM | 6.10 |
| CHEMBL4085150 | — | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL4064668 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL4073256 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL4075227 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL4103375 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL4102555 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL14 | CARBACHOL | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL4103087 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL4085451 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL4094819 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL4071109 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL4072787 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL4070055 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL4089027 | — | Ki | = | 9200.0 | nM | 5.04 |
| CHEMBL4061390 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL4099673 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL4060823 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL4095626 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL4092348 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL4091934 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL4061384 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL4083241 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL4099667 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL4097248 | — | Ki | = | 26000.0 | nM | 4.58 |
| CHEMBL4074319 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL4084607 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL4091032 | — | Ki | = | 39000.0 | nM | 4.41 |
| CHEMBL4070061 | — | Ki | = | 46000.0 | nM | 4.34 |
| CHEMBL4092769 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL4095774 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL146953 | — | Ki | > | 50000.0 | nM | - |