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Compound Detail

CHEMBL4073256

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CNCCc1cccc(OC)c1

Basic Information

ChEMBL ID CHEMBL4073256
Phase Preclinical
Structure Type MOL
InChI Key MCGDBHZRFQKLBT-UHFFFAOYSA-N
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

165.2
MW (Da)
1.46
ALogP
2
HBA
1
HBD
21.3
PSA (Ų)
0.73
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C10H15NO
MW 165.24
Aromatic Rings 1
Heavy Atoms 12
NP-Likeness -0.15

Activity Summary

Ki 3 meas. best 6.13
EC50 1 meas. best 5.09

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL216
Ki 6.13 6.13 740.0 1
Muscarinic acetylcholine receptor M3
CHEMBL245
Ki 6.11 6.11 780.0 1
Muscarinic acetylcholine receptor M2
CHEMBL211
Ki 6.0 6.0 1000.0 1
Muscarinic acetylcholine receptor M2
CHEMBL211
EC50 5.09 5.09 8200.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
29094937 10.1021/acs.jmedchem.7b01113 Muscarinic acetylcholine receptor M2 3
29094937 10.1021/acs.jmedchem.7b01113 Muscarinic acetylcholine receptor M1 1
29094937 10.1021/acs.jmedchem.7b01113 Muscarinic acetylcholine receptor M3 1

Data from ChEMBL 36 via Core Engine