Assay Detail
Binding
CHEMBL4026880
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M3 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Design and Discovery of New M2 Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 5.26 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4100938 | — | — | 1 | 7.39 |
| CHEMBL4065555 | — | — | 1 | 6.85 |
| CHEMBL4102555 | — | — | 1 | 6.68 |
| CHEMBL4069313 | — | — | 1 | 6.26 |
| CHEMBL4081662 | — | — | 1 | 6.21 |
| CHEMBL4093215 | — | — | 1 | 6.16 |
| CHEMBL4073256 | — | — | 1 | 6.11 |
| CHEMBL4075227 | — | — | 1 | 6.08 |
| CHEMBL4085150 | — | — | 1 | 5.70 |
| CHEMBL4103375 | — | — | 1 | 5.41 |
| CHEMBL4085451 | — | — | 1 | 5.40 |
| CHEMBL4072787 | — | — | 1 | 5.39 |
| CHEMBL4071109 | — | — | 1 | 5.33 |
| CHEMBL667 | ACETYLCHOLINE | 4.0 | 1 | 5.33 |
| CHEMBL4094819 | — | — | 1 | 5.24 |
| CHEMBL4070055 | — | — | 1 | 5.24 |
| CHEMBL4060823 | — | — | 1 | 5.20 |
| CHEMBL4061384 | — | — | 1 | 5.06 |
| CHEMBL4083241 | — | — | 1 | 5.00 |
| CHEMBL4089027 | — | — | 1 | 4.96 |
| CHEMBL4061390 | — | — | 1 | 4.92 |
| CHEMBL4084607 | — | — | 1 | 4.92 |
| CHEMBL4092348 | — | — | 1 | 4.89 |
| CHEMBL4064668 | — | — | 1 | 4.85 |
| CHEMBL4103087 | — | — | 1 | 4.80 |
| CHEMBL4092769 | — | — | 1 | 4.70 |
| CHEMBL4099667 | — | — | 1 | 4.68 |
| CHEMBL4097248 | — | — | 1 | 4.62 |
| CHEMBL4095626 | — | — | 1 | 4.60 |
| CHEMBL146953 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4100938 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL4065555 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL4102555 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL4069313 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL4081662 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL4093215 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL4073256 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL4075227 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL4085150 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL4103375 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL4085451 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL4072787 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL4071109 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL667 | ACETYLCHOLINE | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL4070055 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL4094819 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL4060823 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL4061384 | — | Ki | = | 8700.0 | nM | 5.06 |
| CHEMBL4083241 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL4089027 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL4061390 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL4084607 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL4092348 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL4064668 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL4103087 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL4092769 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL4099667 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL4097248 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL4095626 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL146953 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL4099673 | — | Ki | = | 36000.0 | nM | 4.44 |
| CHEMBL4070061 | — | Ki | = | 42000.0 | nM | 4.38 |
| CHEMBL4074319 | — | Ki | = | 43000.0 | nM | 4.37 |
| CHEMBL14 | CARBACHOL | Ki | = | 51000.0 | nM | 4.29 |
| CHEMBL4091032 | — | Ki | = | 75000.0 | nM | 4.12 |
| CHEMBL4095774 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4091934 | — | Ki | > | 50000.0 | nM | - |