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Compound Detail

CHEMBL4070061

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CN1CCCC(OCc2cccnc2)C1

Basic Information

ChEMBL ID CHEMBL4070061
Phase Preclinical
Structure Type MOL
InChI Key ICELNYAJAJVNKF-UHFFFAOYSA-N
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

206.3
MW (Da)
1.69
ALogP
3
HBA
0
HBD
25.4
PSA (Ų)
0.75
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C12H18N2O
MW 206.29
Aromatic Rings 1
Heavy Atoms 15
NP-Likeness -1.00

Activity Summary

Ki 3 meas. best 4.7
EC50 1 meas. best 4.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL216
Ki 4.7 4.7 20000.0 1
Muscarinic acetylcholine receptor M3
CHEMBL245
Ki 4.38 4.38 42000.0 1
Muscarinic acetylcholine receptor M2
CHEMBL211
Ki 4.34 4.34 46000.0 1
Muscarinic acetylcholine receptor M2
CHEMBL211
EC50 4.3 4.3 50000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
29094937 10.1021/acs.jmedchem.7b01113 Muscarinic acetylcholine receptor M2 3
29094937 10.1021/acs.jmedchem.7b01113 Muscarinic acetylcholine receptor M1 1
29094937 10.1021/acs.jmedchem.7b01113 Muscarinic acetylcholine receptor M3 1

Data from ChEMBL 36 via Core Engine