Assay Detail
ADMET
CHEMBL4028923
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 10 mins by membrane vesicle transport assay
629
Total Activities
629
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
ATP-binding cassette sub-family C member 3 (CHEMBL5918) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 629 | 4.52 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL589973 | — | — | 1 | 5.96 |
| CHEMBL1200692 | OLMESARTAN MEDOXOMIL | 4.0 | 1 | 5.70 |
| CHEMBL1481 | GLIMEPIRIDE | 4.0 | 1 | 5.19 |
| CHEMBL813 | EPROSARTAN | 4.0 | 1 | 5.18 |
| CHEMBL15177 | MK-571 | — | 1 | 5.03 |
| CHEMBL77305 | RUBITECAN | 3.0 | 1 | 4.99 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 4.96 |
| CHEMBL393220 | ATORVASTATIN CALCIUM | 4.0 | 1 | 4.85 |
| CHEMBL421 | SULFASALAZINE | 4.0 | 1 | 4.84 |
| CHEMBL1200865 | LOTEPREDNOL ETABONATE | 4.0 | 1 | 4.81 |
| CHEMBL1272 | REPAGLINIDE | 4.0 | 1 | 4.78 |
| CHEMBL452231 | TENIPOSIDE | 4.0 | 1 | 4.69 |
| CHEMBL1292 | CLOFAZIMINE | 4.0 | 1 | 4.68 |
| CHEMBL1513 | IRBESARTAN | 4.0 | 1 | 4.68 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 4.68 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 4.64 |
| CHEMBL383634 | GLIQUIDONE | 2.0 | 1 | 4.62 |
| CHEMBL495 | ALPROSTADIL | 4.0 | 1 | 4.57 |
| CHEMBL408 | TROGLITAZONE | 4.0 | 1 | 4.51 |
| CHEMBL472 | GLYBURIDE | 4.0 | 1 | 4.48 |
| CHEMBL953 | ENTACAPONE | 4.0 | 1 | 4.46 |
| CHEMBL957 | BOSENTAN | 4.0 | 1 | 4.38 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 4.38 |
| CHEMBL4063475 | — | — | 1 | 4.38 |
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | 4.34 |
| CHEMBL282724 | SITAXENTAN | 4.0 | 1 | 4.34 |
| CHEMBL1370 | BUDESONIDE | 4.0 | 1 | 4.26 |
| CHEMBL2220442 | FLUVASTATIN | 4.0 | 1 | 4.24 |
| CHEMBL1744447 | ROSUVASTATIN CALCIUM | 4.0 | 1 | 4.23 |
| CHEMBL1017 | TELMISARTAN | 4.0 | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL589973 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1200692 | OLMESARTAN MEDOXOMIL | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1481 | GLIMEPIRIDE | IC50 | = | 6390.0 | nM | 5.19 |
| CHEMBL813 | EPROSARTAN | IC50 | = | 6650.0 | nM | 5.18 |
| CHEMBL15177 | MK-571 | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL77305 | RUBITECAN | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL163 | RITONAVIR | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL393220 | ATORVASTATIN CALCIUM | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL421 | SULFASALAZINE | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL1200865 | LOTEPREDNOL ETABONATE | IC50 | = | 15520.0 | nM | 4.81 |
| CHEMBL1272 | REPAGLINIDE | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL452231 | TENIPOSIDE | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL1513 | IRBESARTAN | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL729 | LOPINAVIR | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL1292 | CLOFAZIMINE | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL383634 | GLIQUIDONE | IC50 | = | 23850.0 | nM | 4.62 |
| CHEMBL495 | ALPROSTADIL | IC50 | = | 26900.0 | nM | 4.57 |
| CHEMBL408 | TROGLITAZONE | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL472 | GLYBURIDE | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL953 | ENTACAPONE | IC50 | = | 35100.0 | nM | 4.46 |
| CHEMBL957 | BOSENTAN | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL114 | SAQUINAVIR | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL4063475 | — | IC50 | = | 41200.0 | nM | 4.38 |
| CHEMBL282724 | SITAXENTAN | IC50 | = | 45400.0 | nM | 4.34 |
| CHEMBL56337 | EPALRESTAT | IC50 | = | 45800.0 | nM | 4.34 |
| CHEMBL1370 | BUDESONIDE | IC50 | = | 54500.0 | nM | 4.26 |
| CHEMBL2220442 | FLUVASTATIN | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL1744447 | ROSUVASTATIN CALCIUM | IC50 | = | 58300.0 | nM | 4.23 |
| CHEMBL1017 | TELMISARTAN | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL1617 | RIFAXIMIN | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL374478 | RIFAMPIN | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 71900.0 | nM | 4.14 |
| CHEMBL1096885 | VALRUBICIN | IC50 | = | 76300.0 | nM | 4.12 |
| CHEMBL474579 | CEFOTETAN | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL1660 | RIFAPENTINE | IC50 | = | 80900.0 | nM | 4.09 |
| CHEMBL1908360 | EVEROLIMUS | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL5483011 | INDINAVIR | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL1324 | TOLCAPONE | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL3140361 | ETHAMBUTOL HYDROCHLORIDE | IC50 | = | 88200.0 | nM | 4.05 |
| CHEMBL456 | ETHACRYNIC ACID | IC50 | = | 95900.0 | nM | 4.02 |
| CHEMBL2103772 | RACECADOTRIL | IC50 | = | 99000.0 | nM | 4.00 |
| CHEMBL21731 | MAPROTILINE | IC50 | > | 133000.0 | nM | - |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | > | 133000.0 | nM | - |
| CHEMBL16073 | PHENACETIN | IC50 | > | 133000.0 | nM | - |
| CHEMBL521606 | NADOLOL | IC50 | > | 133000.0 | nM | - |
| CHEMBL802 | MINOXIDIL | IC50 | > | 133000.0 | nM | - |
| CHEMBL1200735 | MOXIFLOXACIN HYDROCHLORIDE | IC50 | > | 133000.0 | nM | - |
| CHEMBL245019 | MIZORIBINE | IC50 | > | 133000.0 | nM | - |