Assay Detail
Binding
CHEMBL4039162
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Inhibition of human dopamine D1 receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Return of D4 Dopamine Receptor Antagonists in Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.53 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81330 | — | — | 1 | 6.39 |
| CHEMBL4096543 | — | — | 1 | 5.55 |
| CHEMBL310843 | — | — | 1 | 5.26 |
| CHEMBL7927 | FAUC 113 | — | 1 | 4.92 |
| CHEMBL267014 | L-745870 | — | 1 | - |
| CHEMBL127257 | — | — | 1 | - |
| CHEMBL146556 | — | — | 1 | - |
| CHEMBL69759 | SONEPIPRAZOLE | 2.0 | 1 | - |
| CHEMBL3335537 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81330 | — | Ki | = | 411.0 | nM | 6.39 |
| CHEMBL4096543 | — | Ki | = | 2830.0 | nM | 5.55 |
| CHEMBL310843 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL7927 | FAUC 113 | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL267014 | L-745870 | Ki | > | 10000.0 | nM | - |
| CHEMBL127257 | — | Ki | > | 8000.0 | nM | - |
| CHEMBL146556 | — | Ki | > | 3000.0 | nM | - |
| CHEMBL69759 | SONEPIPRAZOLE | Ki | > | 8378.0 | nM | - |
| CHEMBL3335537 | — | Ki | > | 100000.0 | nM | - |