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Assay Detail

CHEMBL4132273

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C4 amastigotes infected in rat L6 cells after 96 hrs by CPRG/nonidet-based inverted microscopic analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Cell Type L6
Confidence 1 — Organism
Curated By Intermediate

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

The antitrypanosomal and antitubercular activity of some nitro(triazole/imidazole)-based aromatic amines.
Papadopoulou MV, Bloomer WD, Rosenzweig HS, Kaiser M.
Eur J Med Chem (2017) 138 : 1106 -1113
PubMed 28763645 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.82 6.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1922441 1 6.85
CHEMBL4177234 1 6.24
CHEMBL1922440 1 6.22
CHEMBL4168552 1 6.06
CHEMBL1922429 1 5.98
CHEMBL4164033 1 5.96
CHEMBL4165130 1 5.74
CHEMBL4171905 1 5.69
CHEMBL110 BENZNIDAZOLE 4.0 1 5.65
CHEMBL4160631 1 5.63
CHEMBL1922430 1 5.46
CHEMBL4166614 1 4.31

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1922441 IC50 = 140.0 nM 6.85
CHEMBL4177234 IC50 = 574.0 nM 6.24
CHEMBL1922440 IC50 = 607.0 nM 6.22
CHEMBL4168552 IC50 = 872.0 nM 6.06
CHEMBL1922429 IC50 = 1040.0 nM 5.98
CHEMBL4164033 IC50 = 1110.0 nM 5.96
CHEMBL4165130 IC50 = 1830.0 nM 5.74
CHEMBL4171905 IC50 = 2040.0 nM 5.69
CHEMBL110 BENZNIDAZOLE IC50 = 2240.0 nM 5.65
CHEMBL4160631 IC50 = 2320.0 nM 5.63
CHEMBL1922430 IC50 = 3510.0 nM 5.46
CHEMBL4166614 IC50 = 48600.0 nM 4.31