Assay Detail
Functional
CHEMBL4133992
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV NL4.3 harboring renilla luciferase infected in human MT2 cells pretreated for 2 hrs followed by viral infection measured after 48 to 96 hrs post infection by luciferase reporter gene assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
Environmentally Friendly Procedure Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking for the Discovery of Potent Antiviral Compounds from Euphorbia semiperfoliata.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.56 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4165007 | — | — | 1 | 7.89 |
| CHEMBL4170130 | — | — | 1 | 7.27 |
| CHEMBL170518 | PROSTRATIN | — | 1 | 6.65 |
| CHEMBL4168419 | — | — | 1 | 5.59 |
| CHEMBL2375779 | — | — | 1 | 5.38 |
| CHEMBL4174527 | — | — | 1 | - |
| CHEMBL4169508 | — | — | 1 | - |
| CHEMBL279115 | PHORBOL MYRISTATE ACETATE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4165007 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4170130 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL170518 | PROSTRATIN | EC50 | = | 226.0 | nM | 6.65 |
| CHEMBL4168419 | — | EC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL2375779 | — | EC50 | = | 4190.0 | nM | 5.38 |
| CHEMBL4174527 | — | EC50 | - | — | - | |
| CHEMBL4169508 | — | EC50 | - | — | - | |
| CHEMBL279115 | PHORBOL MYRISTATE ACETATE | EC50 | - | — | - |