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Assay Detail

CHEMBL4139429

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against bloodstream forms of Trypanosoma cruzi Y isolated from parasite infected Albino Swiss mouse assessed as induction of parasite lysis incubated for 24 hrs by Neubauer chamber based cell counting method
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 1 — Organism
Curated By Intermediate

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Rhodium-catalyzed C-H bond activation for the synthesis of quinonoid compounds: Significant Anti-Trypanosoma cruzi activities and electrochemical studies of functionalized quinones.
Jardim GAM, Silva TL, Goulart MOF, de Simone CA, Barbosa JMC, Salomão K, de Castro SL, Bower JF, da Silva Júnior EN.
Eur J Med Chem (2017) 136 : 406 -419
PubMed 28521262 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 41 5.49 6.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL240965 1 6.80
CHEMBL4173823 1 6.72
CHEMBL4166151 1 6.66
CHEMBL4165449 1 6.31
CHEMBL4160933 1 6.25
CHEMBL4174070 1 6.23
CHEMBL4167563 1 6.07
CHEMBL4162297 1 6.00
CHEMBL1989223 1 5.99
CHEMBL4172151 1 5.95
CHEMBL4161242 1 5.93
CHEMBL4177178 1 5.91
CHEMBL4169580 1 5.87
CHEMBL349148 2-Bromo-1,4-naphthoquinone 1 5.86
CHEMBL4169275 1 5.86
CHEMBL295316 PLUMBAGIN 1.0 1 5.86
CHEMBL4168874 1 5.79
CHEMBL4168732 1 5.79
CHEMBL4161549 1 5.75
CHEMBL4160486 1 5.71
CHEMBL4163114 1 5.66
CHEMBL4175198 1 5.65
CHEMBL4177434 1 5.45
CHEMBL4169164 1 5.39
CHEMBL4166557 1 5.22
CHEMBL43612 JUGLONE 1 5.19
CHEMBL4166794 1 5.14
CHEMBL4172960 1 5.12
CHEMBL110 BENZNIDAZOLE 4.0 1 5.01
CHEMBL4170706 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL240965 IC50 = 160.0 nM 6.80
CHEMBL4173823 IC50 = 190.0 nM 6.72
CHEMBL4166151 IC50 = 220.0 nM 6.66
CHEMBL4165449 IC50 = 490.0 nM 6.31
CHEMBL4160933 IC50 = 560.0 nM 6.25
CHEMBL4174070 IC50 = 590.0 nM 6.23
CHEMBL4167563 IC50 = 850.0 nM 6.07
CHEMBL4162297 IC50 = 990.0 nM 6.00
CHEMBL1989223 IC50 = 1020.0 nM 5.99
CHEMBL4172151 IC50 = 1130.0 nM 5.95
CHEMBL4161242 IC50 = 1170.0 nM 5.93
CHEMBL4177178 IC50 = 1240.0 nM 5.91
CHEMBL4169580 IC50 = 1350.0 nM 5.87
CHEMBL295316 PLUMBAGIN IC50 = 1380.0 nM 5.86
CHEMBL4169275 IC50 = 1380.0 nM 5.86
CHEMBL349148 2-Bromo-1,4-naphthoquinone IC50 = 1370.0 nM 5.86
CHEMBL4168874 IC50 = 1610.0 nM 5.79
CHEMBL4168732 IC50 = 1620.0 nM 5.79
CHEMBL4161549 IC50 = 1790.0 nM 5.75
CHEMBL4160486 IC50 = 1940.0 nM 5.71
CHEMBL4163114 IC50 = 2200.0 nM 5.66
CHEMBL4175198 IC50 = 2250.0 nM 5.65
CHEMBL4177434 IC50 = 3540.0 nM 5.45
CHEMBL4169164 IC50 = 4060.0 nM 5.39
CHEMBL4166557 IC50 = 6030.0 nM 5.22
CHEMBL43612 JUGLONE IC50 = 6510.0 nM 5.19
CHEMBL4166794 IC50 = 7260.0 nM 5.14
CHEMBL4172960 IC50 = 7570.0 nM 5.12
CHEMBL110 BENZNIDAZOLE IC50 = 9680.0 nM 5.01
CHEMBL4170706 IC50 = 10070.0 nM 5.00
CHEMBL4167318 IC50 = 12770.0 nM 4.89
CHEMBL4160067 IC50 = 14090.0 nM 4.85
CHEMBL4163865 IC50 = 15400.0 nM 4.81
CHEMBL4160547 IC50 = 15950.0 nM 4.80
CHEMBL4177100 IC50 = 20770.0 nM 4.68
CHEMBL4171141 IC50 = 21540.0 nM 4.67
CHEMBL4168381 IC50 = 23950.0 nM 4.62
CHEMBL4162710 IC50 = 24800.0 nM 4.61
CHEMBL4171745 IC50 = 26990.0 nM 4.57
CHEMBL4170637 IC50 = 42000.0 nM 4.38
CHEMBL4175191 IC50 = 83420.0 nM 4.08