Assay Detail
Functional
CHEMBL4139737
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human T47D cells assessed as reduction in cell viability after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of novel indole derivatives as promising DNA-binding agents and evaluation of antitumor and antitopoisomerase I activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.33 | 5.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1910509 | — | — | 1 | 5.71 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.34 |
| CHEMBL4161864 | — | — | 1 | 4.93 |
| CHEMBL4167215 | — | — | 1 | - |
| CHEMBL4175081 | — | — | 1 | - |
| CHEMBL1917018 | — | — | 1 | - |
| CHEMBL4175862 | — | — | 1 | - |
| CHEMBL541474 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1910509 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 4610.0 | nM | 5.34 |
| CHEMBL4161864 | — | IC50 | = | 11720.0 | nM | 4.93 |
| CHEMBL4167215 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4175081 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1917018 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4175862 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL541474 | — | IC50 | > | 50000.0 | nM | - |