Assay Detail
Functional
CHEMBL4143002
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against beta-galactosidase expressing nifurtimox-sensitive Trypanosoma cruzi Tulahuen CL2 infected in human MRC5 SV2 cells assessed as decrease in parasite burden after 168 hrs by spectrophotometric method
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel triazine dimers with potent antitrypanosomal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 62 | 5.25 | 6.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2207879 | — | — | 1 | 6.23 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 6.16 |
| CHEMBL2207895 | — | — | 1 | 5.76 |
| CHEMBL2207899 | — | — | 1 | 5.75 |
| CHEMBL2207914 | — | — | 1 | 5.61 |
| CHEMBL2207897 | — | — | 1 | 5.60 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 5.59 |
| CHEMBL3338054 | — | — | 1 | 5.35 |
| CHEMBL2207898 | — | — | 1 | 5.33 |
| CHEMBL3338023 | — | — | 1 | 5.31 |
| CHEMBL2207915 | — | — | 1 | 5.27 |
| CHEMBL470025 | — | — | 1 | 5.18 |
| CHEMBL302791 | — | — | 1 | 5.17 |
| CHEMBL2207894 | — | — | 1 | 5.16 |
| CHEMBL71659 | — | — | 1 | 5.15 |
| CHEMBL3338026 | — | — | 1 | 5.13 |
| CHEMBL71521 | — | — | 1 | 5.13 |
| CHEMBL2207885 | — | — | 1 | 5.08 |
| CHEMBL3338022 | — | — | 1 | 5.06 |
| CHEMBL421114 | — | — | 1 | 5.06 |
| CHEMBL2207912 | — | — | 1 | 5.05 |
| CHEMBL74174 | — | — | 1 | 4.94 |
| CHEMBL3338052 | — | — | 1 | 4.82 |
| CHEMBL2207594 | — | — | 1 | 4.77 |
| CHEMBL2207901 | — | — | 1 | 4.63 |
| CHEMBL2207913 | — | — | 1 | 4.31 |
| CHEMBL4165796 | — | — | 1 | - |
| CHEMBL2207896 | — | — | 1 | - |
| CHEMBL2207880 | — | — | 1 | - |
| CHEMBL2207881 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2207879 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2207895 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL2207899 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL2207914 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL2207897 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL3338054 | — | IC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL2207898 | — | IC50 | = | 4680.0 | nM | 5.33 |
| CHEMBL3338023 | — | IC50 | = | 4870.0 | nM | 5.31 |
| CHEMBL2207915 | — | IC50 | = | 5410.0 | nM | 5.27 |
| CHEMBL470025 | — | IC50 | = | 6650.0 | nM | 5.18 |
| CHEMBL302791 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL2207894 | — | IC50 | = | 6890.0 | nM | 5.16 |
| CHEMBL71659 | — | IC50 | = | 7150.0 | nM | 5.15 |
| CHEMBL3338026 | — | IC50 | = | 7450.0 | nM | 5.13 |
| CHEMBL71521 | — | IC50 | = | 7370.0 | nM | 5.13 |
| CHEMBL2207885 | — | IC50 | = | 8320.0 | nM | 5.08 |
| CHEMBL3338022 | — | IC50 | = | 8660.0 | nM | 5.06 |
| CHEMBL421114 | — | IC50 | = | 8690.0 | nM | 5.06 |
| CHEMBL2207912 | — | IC50 | = | 8820.0 | nM | 5.05 |
| CHEMBL74174 | — | IC50 | = | 11510.0 | nM | 4.94 |
| CHEMBL3338052 | — | IC50 | = | 14980.0 | nM | 4.82 |
| CHEMBL2207594 | — | IC50 | = | 17080.0 | nM | 4.77 |
| CHEMBL2207901 | — | IC50 | = | 23540.0 | nM | 4.63 |
| CHEMBL2207913 | — | IC50 | = | 49050.0 | nM | 4.31 |
| CHEMBL2203849 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2207900 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2207909 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2207908 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2207907 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2207906 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2207905 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2207904 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2207903 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2207902 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2203851 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2203850 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4165796 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2207919 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2207910 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3338053 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3338021 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3338007 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2207883 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2207884 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4175939 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2207881 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2207880 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2207896 | — | IC50 | > | 64000.0 | nM | - |