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Assay Detail

CHEMBL4145967

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity Trypanosoma cruzi Y Tc2 epimastigotes measured after 72 hrs
41
Total Activities
24
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 1 — Organism
Curated By Intermediate

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Investigating the structure-activity relationships of N'-[(5-nitrofuran-2-yl) methylene] substituted hydrazides against Trypanosoma cruzi to design novel active compounds.
Palace-Berl F, Pasqualoto KFM, Zingales B, Moraes CB, Bury M, Franco CH, da Silva Neto AL, Murayama JS, Nunes SL, Silva MN, Tavares LC.
Eur J Med Chem (2018) 144 : 29 -40
PubMed 29247858 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
log1/IC50 21 - -
IC50 20 5.02 5.86

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4172913 2 5.86
CHEMBL4165020 2 5.83
CHEMBL4161166 2 5.60
CHEMBL4170340 2 5.59
CHEMBL4172085 2 5.26
CHEMBL4163560 2 5.15
CHEMBL3260874 2 5.04
CHEMBL4171032 2 5.03
CHEMBL3260873 2 5.01
CHEMBL480770 2 4.98
CHEMBL290960 NIFURTIMOX 4.0 2 4.89
CHEMBL4160617 2 4.85
CHEMBL4164405 2 4.76
CHEMBL4160426 2 4.60
CHEMBL110 BENZNIDAZOLE 4.0 1 4.39
CHEMBL416237 2 4.36
CHEMBL4167659 2 4.10
CHEMBL244888 NIFUROXAZIDE 3.0 2 -
CHEMBL3260870 1 -
CHEMBL481348 1 -
CHEMBL2413121 1 -
CHEMBL3415956 1 -
CHEMBL3260878 1 -
CHEMBL3415957 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4172913 IC50 = 1370.0 nM 5.86
CHEMBL4165020 IC50 = 1470.0 nM 5.83
CHEMBL4161166 IC50 = 2500.0 nM 5.60
CHEMBL4170340 IC50 = 2550.0 nM 5.59
CHEMBL4172085 IC50 = 5510.0 nM 5.26
CHEMBL4163560 IC50 = 7150.0 nM 5.15
CHEMBL3260874 IC50 = 9110.0 nM 5.04
CHEMBL4171032 IC50 = 9280.0 nM 5.03
CHEMBL3260873 IC50 = 9740.0 nM 5.01
CHEMBL480770 IC50 = 10580.0 nM 4.98
CHEMBL290960 NIFURTIMOX IC50 = 12840.0 nM 4.89
CHEMBL4160617 IC50 = 14220.0 nM 4.85
CHEMBL4164405 IC50 = 17280.0 nM 4.76
CHEMBL4160426 IC50 = 24860.0 nM 4.60
CHEMBL110 BENZNIDAZOLE IC50 = 40230.0 nM 4.39
CHEMBL416237 IC50 = 44130.0 nM 4.36
CHEMBL4167659 IC50 = 80230.0 nM 4.10
CHEMBL481348 IC50 - -
CHEMBL244888 NIFUROXAZIDE IC50 = 300000.0 nM -
CHEMBL3260870 IC50 - -
CHEMBL244888 NIFUROXAZIDE log1/IC50 = 3.52 -
CHEMBL290960 NIFURTIMOX log1/IC50 = 4.89 -
CHEMBL2413121 log1/IC50 = 5.51 -
CHEMBL3415956 log1/IC50 = 5.47 -
CHEMBL3260878 log1/IC50 = 5.46 -
CHEMBL3415957 log1/IC50 = 5.93 -
CHEMBL4167659 log1/IC50 = 4.09 -
CHEMBL4171032 log1/IC50 = 5.03 -
CHEMBL4160426 log1/IC50 = 4.6 -
CHEMBL4172913 log1/IC50 = 5.86 -
CHEMBL4170340 log1/IC50 = 5.59 -
CHEMBL4161166 log1/IC50 = 5.6 -
CHEMBL480770 log1/IC50 = 4.98 -
CHEMBL4160617 log1/IC50 = 4.85 -
CHEMBL4163560 log1/IC50 = 5.15 -
CHEMBL416237 log1/IC50 = 4.36 -
CHEMBL3260873 log1/IC50 = 5.01 -
CHEMBL3260874 log1/IC50 = 5.04 -
CHEMBL4165020 log1/IC50 = 5.83 -
CHEMBL4172085 log1/IC50 = 5.26 -
CHEMBL4164405 log1/IC50 = 4.76 -