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Assay Detail

CHEMBL4181864

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytoprotective activity against tunicamycin-induced cell death in mouse HT22 cells after 24 hrs by MTT assay
ChEMBL ↗
48
Total Activities
40
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type HT-22
Confidence 1 — Organism
Curated By Intermediate

Target

HT-22 (CHEMBL614316) ↗
Type CELL-LINE
Organism Mus musculus

Publication

Indirubin derivatives protect against endoplasmic reticulum stress-induced cytotoxicity and down-regulate CHOP levels in HT22 cells.
Kosuge Y, Saito H, Haraguchi T, Ichimaru Y, Ohashi S, Miyagishi H, Kobayashi S, Ishige K, Miyairi S, Ito Y.
Bioorg Med Chem Lett (2017) 27 : 5122 -5125
PubMed 29122482 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Activity 40 - -
EC50 8 4.56 5.01

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1276634 — — 2 5.01
CHEMBL1966883 — — 2 4.67
CHEMBL4212224 — — 2 4.62
CHEMBL1830060 — — 2 4.61
CHEMBL4064909 — — 2 4.52
CHEMBL1084938 — — 2 4.51
CHEMBL1231469 — — 2 4.44
CHEMBL253770 INDIRUBIN 2 — 2 4.07
CHEMBL4207337 — — 1 -
CHEMBL1830067 — — 1 -
CHEMBL524052 — — 1 -
CHEMBL4212992 — — 1 -
CHEMBL1830059 — — 1 -
CHEMBL216543 — — 1 -
CHEMBL4210770 — — 1 -
CHEMBL1830055 — — 1 -
CHEMBL1830054 — — 1 -
CHEMBL4077311 — — 1 -
CHEMBL1276127 INDIRUBIN 2.0 1 -
CHEMBL3401494 — — 1 -
CHEMBL4204271 — — 1 -
CHEMBL1986018 — — 1 -
CHEMBL4216702 — — 1 -
CHEMBL4205017 — — 1 -
CHEMBL4212264 — — 1 -
CHEMBL1097359 — — 1 -
CHEMBL4207904 — — 1 -
CHEMBL2003361 — — 1 -
CHEMBL4096373 — — 1 -
CHEMBL1980404 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1276634 — EC50 = 9800.0 nM 5.01
CHEMBL1966883 — EC50 = 21300.0 nM 4.67
CHEMBL4212224 — EC50 = 23700.0 nM 4.62
CHEMBL1830060 — EC50 = 24500.0 nM 4.61
CHEMBL4064909 — EC50 = 30000.0 nM 4.52
CHEMBL1084938 — EC50 = 30800.0 nM 4.51
CHEMBL1231469 — EC50 = 36000.0 nM 4.44
CHEMBL253770 INDIRUBIN 2 EC50 = 85800.0 nM 4.07
CHEMBL1830065 — Activity - — -
CHEMBL524052 — Activity - — -
CHEMBL1830064 — Activity - — -
CHEMBL1830056 — Activity - — -
CHEMBL1830055 — Activity - — -
CHEMBL1830054 — Activity - — -
CHEMBL4210770 — Activity - — -
CHEMBL4212224 — Activity - — -
CHEMBL4207337 — Activity - — -
CHEMBL1276127 INDIRUBIN Activity - — -
CHEMBL1966883 — Activity - — -
CHEMBL4203289 — Activity - — -
CHEMBL1830057 — Activity - — -
CHEMBL1830058 — Activity - — -
CHEMBL253770 INDIRUBIN 2 Activity - — -
CHEMBL1830062 — Activity - — -
CHEMBL1830063 — Activity - — -
CHEMBL1496938 — Activity - — -
CHEMBL1830067 — Activity - — -
CHEMBL1231469 — Activity - — -
CHEMBL4205017 — Activity - — -
CHEMBL4212264 — Activity - — -
CHEMBL4077311 — Activity - — -
CHEMBL4096373 — Activity - — -
CHEMBL1084938 — Activity - — -
CHEMBL1980404 — Activity - — -
CHEMBL2003361 — Activity - — -
CHEMBL4207904 — Activity - — -
CHEMBL1097359 — Activity - — -
CHEMBL4212992 — Activity - — -
CHEMBL216543 — Activity - — -
CHEMBL4216702 — Activity - — -
CHEMBL1986018 — Activity - — -
CHEMBL4204271 — Activity - — -
CHEMBL3401494 — Activity - — -
CHEMBL1276634 — Activity - — -
CHEMBL1830060 — Activity - — -
CHEMBL4064909 — Activity - — -
CHEMBL1830059 — Activity - — -
CHEMBL1830066 — Activity - — -