Assay Detail
ADMET
CHEMBL4182258
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to His-tagged BRD2 bromodomain 1 (unknown origin) by SPR assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 6.98 | 7.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4205876 | — | — | 1 | 7.18 |
| CHEMBL4209110 | — | — | 1 | 7.10 |
| CHEMBL4202664 | — | — | 1 | 7.00 |
| CHEMBL1957266 | — | — | 1 | 6.98 |
| CHEMBL4210405 | — | — | 1 | 6.98 |
| CHEMBL4206677 | — | — | 1 | 6.98 |
| CHEMBL4207106 | — | — | 1 | 6.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4205876 | — | Kd | = | 66.0 | nM | 7.18 |
| CHEMBL4209110 | — | Kd | = | 80.0 | nM | 7.10 |
| CHEMBL4202664 | — | Kd | = | 99.0 | nM | 7.00 |
| CHEMBL1957266 | — | Kd | = | 104.0 | nM | 6.98 |
| CHEMBL4210405 | — | Kd | = | 105.0 | nM | 6.98 |
| CHEMBL4206677 | — | Kd | = | 104.0 | nM | 6.98 |
| CHEMBL4207106 | — | Kd | = | 245.0 | nM | 6.61 |