Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL4206677

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CC(=O)N1c2ccc(-c3cc[nH]c3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4206677
Phase Preclinical
Structure Type MOL
InChI Key NGBVNAZGPQQGHB-SCLBCKFNSA-N
1
Targets
8
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

355.4
MW (Da)
4.00
ALogP
3
HBA
2
HBD
74.4
PSA (Ų)
0.87
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H25N3O3
MW 355.44
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness -0.37

Activity Summary

Kd 6 meas. best 7.7
IC50 2 meas. best 6.39

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Bromodomain-containing protein 2
CHEMBL1293289
 Kd 7.7 7.2617 19.9 6
Bromodomain-containing protein 2
CHEMBL1293289
 IC50 6.39 6.0 410.0 2

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Bromodomain-containing protein 2 Kd = 19.94 nM 7.7 Binding affinity to BRD2 bromodomain 2 (348 to 455 residues) (unknown origin) by... 29170024
Bromodomain-containing protein 2 Kd = 20.0 nM 7.7 Isothermal Titration Calorimetry Analysis of Binding to Brd2-BD1 and Brd2-BD2: B... -
Bromodomain-containing protein 2 Kd = 77.0 nM 7.11 Binding affinity to His-tagged BRD2 bromodomain 2 (unknown origin) by SPR assay 29170024
Bromodomain-containing protein 2 Kd = 91.53 nM 7.04 Binding affinity to BRD2 bromodomain 1 (74 to 194 residues) (unknown origin) by ... 29170024
Bromodomain-containing protein 2 Kd = 92.0 nM 7.04 Isothermal Titration Calorimetry Analysis of Binding to Brd2-BD1 and Brd2-BD2: B... -
Bromodomain-containing protein 2 Kd = 104.0 nM 6.98 Binding affinity to His-tagged BRD2 bromodomain 1 (unknown origin) by SPR assay 29170024
Bromodomain-containing protein 2 IC50 = 410.0 nM 6.39 Inhibition of recombinant human BRD2 bromodomain 2 (342 to 460 residues) using b... 29170024
Bromodomain-containing protein 2 IC50 = 2480.0 nM 5.61 Inhibition of recombinant human BRD2 bromodomain 1 (49 to 170 residues) using bi... 29170024

Literature References

PubMed DOI Target Context # Activities
29170024 10.1016/j.bmc.2017.10.042 Bromodomain-containing protein 2 6
29170024 10.1016/j.bmc.2017.10.042 Unchecked 3

Data from ChEMBL 36 via Core Engine