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Compound Detail

CHEMBL4207106

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CC(=O)N1c2ccc(-c3ccoc3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4207106
Phase Preclinical
Structure Type MOL
InChI Key LHFQBNJRTJCMRA-SCLBCKFNSA-N
1
Targets
8
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

356.4
MW (Da)
4.27
ALogP
4
HBA
1
HBD
71.8
PSA (Ų)
0.89
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H24N2O4
MW 356.42
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness -0.20

Activity Summary

Kd 6 meas. best 6.83
IC50 2 meas. best 5.72

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Bromodomain-containing protein 2
CHEMBL1293289
 Kd 6.83 6.6767 148.0 6
Bromodomain-containing protein 2
CHEMBL1293289
 IC50 5.72 5.48 1910.0 2

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Bromodomain-containing protein 2 Kd = 148.0 nM 6.83 Binding affinity to His-tagged BRD2 bromodomain 2 (unknown origin) by SPR assay 29170024
Bromodomain-containing protein 2 Kd = 162.47 nM 6.79 Binding affinity to BRD2 bromodomain 1 (74 to 194 residues) (unknown origin) by ... 29170024
Bromodomain-containing protein 2 Kd = 162.0 nM 6.79 Isothermal Titration Calorimetry Analysis of Binding to Brd2-BD1 and Brd2-BD2: B... -
Bromodomain-containing protein 2 Kd = 245.0 nM 6.61 Binding affinity to His-tagged BRD2 bromodomain 1 (unknown origin) by SPR assay 29170024
Bromodomain-containing protein 2 Kd = 299.51 nM 6.52 Binding affinity to BRD2 bromodomain 2 (348 to 455 residues) (unknown origin) by... 29170024
Bromodomain-containing protein 2 Kd = 300.0 nM 6.52 Isothermal Titration Calorimetry Analysis of Binding to Brd2-BD1 and Brd2-BD2: B... -
Bromodomain-containing protein 2 IC50 = 1910.0 nM 5.72 Inhibition of recombinant human BRD2 bromodomain 2 (342 to 460 residues) using b... 29170024
Bromodomain-containing protein 2 IC50 = 5800.0 nM 5.24 Inhibition of recombinant human BRD2 bromodomain 1 (49 to 170 residues) using bi... 29170024

Literature References

PubMed DOI Target Context # Activities
29170024 10.1016/j.bmc.2017.10.042 Bromodomain-containing protein 2 6
29170024 10.1016/j.bmc.2017.10.042 Unchecked 3

Data from ChEMBL 36 via Core Engine