Assay Detail
Functional
CHEMBL4196381
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Antitrypanosomal activity against Trypanosoma brucei Lister 427 bloodstream form after 72 hrs by SYBR Green assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.19 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.80 |
| CHEMBL4210646 | — | — | 1 | 5.64 |
| CHEMBL4206286 | — | — | 1 | 5.13 |
| CHEMBL1276230 | — | — | 1 | 4.77 |
| CHEMBL243187 | — | — | 1 | 4.57 |
| CHEMBL242112 | SALICYLALDEHYDE THIOSEMICARBAZONE | — | 1 | 4.50 |
| CHEMBL398205 | — | — | 1 | 4.50 |
| CHEMBL4204121 | — | — | 1 | 4.46 |
| CHEMBL4203577 | — | — | 1 | 4.35 |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | - |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | - |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4210646 | — | EC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL4206286 | — | EC50 | = | 7450.0 | nM | 5.13 |
| CHEMBL1276230 | — | EC50 | = | 16880.0 | nM | 4.77 |
| CHEMBL243187 | — | EC50 | = | 27130.0 | nM | 4.57 |
| CHEMBL242112 | SALICYLALDEHYDE THIOSEMICARBAZONE | EC50 | = | 31500.0 | nM | 4.50 |
| CHEMBL398205 | — | EC50 | = | 31500.0 | nM | 4.50 |
| CHEMBL4204121 | — | EC50 | = | 34370.0 | nM | 4.46 |
| CHEMBL4203577 | — | EC50 | = | 44360.0 | nM | 4.35 |
| CHEMBL267345 | AMPHOTERICIN B | EC50 | - | — | - | |
| CHEMBL125 | MILTEFOSINE | EC50 | - | — | - | |
| CHEMBL110 | BENZNIDAZOLE | EC50 | - | — | - |