Assay Detail
Functional
CHEMBL4231091
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-parasitic activity against bloodstream trypomastigote stage of wild-type Trypanosoma brucei brucei Lister 427 after 48 hrs by resazurin-based assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 30 | 5.87 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4249714 | — | — | 1 | 9.24 |
| CHEMBL477683 | PHENYLARSINE OXIDE | — | 1 | 8.96 |
| CHEMBL4245918 | — | — | 1 | 8.80 |
| CHEMBL4250711 | — | — | 1 | 8.62 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.48 |
| CHEMBL4244022 | — | — | 1 | 7.50 |
| CHEMBL35241 | DIMINAZENE | 2.0 | 1 | 7.19 |
| CHEMBL4247258 | — | — | 1 | 6.88 |
| CHEMBL4237349 | — | — | 1 | 6.68 |
| CHEMBL4237238 | — | — | 1 | 5.76 |
| CHEMBL4240979 | — | — | 1 | 5.42 |
| CHEMBL4247810 | — | — | 1 | 5.39 |
| CHEMBL4239171 | — | — | 1 | 4.92 |
| CHEMBL4090897 | — | — | 1 | 4.84 |
| CHEMBL4248268 | — | — | 1 | 4.84 |
| CHEMBL4250174 | — | — | 1 | 4.84 |
| CHEMBL4237659 | — | — | 1 | 4.83 |
| CHEMBL328910 | 2,4-DIHYDROXYBENZOIC ACID | — | 1 | 4.77 |
| CHEMBL4251018 | — | — | 1 | 4.75 |
| CHEMBL4237726 | — | — | 1 | 4.75 |
| CHEMBL4244828 | — | — | 1 | 4.57 |
| CHEMBL4068891 | — | — | 1 | 4.50 |
| CHEMBL4241091 | — | — | 1 | 4.48 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | — | 1 | 4.41 |
| CHEMBL4245303 | — | — | 1 | 4.38 |
| CHEMBL4069905 | — | — | 1 | 4.34 |
| CHEMBL4241528 | — | — | 1 | 4.31 |
| CHEMBL4243481 | — | — | 1 | - |
| CHEMBL4249095 | — | — | 1 | - |
| CHEMBL4241625 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4249714 | — | EC50 | = | 0.58 | nM | 9.24 |
| CHEMBL477683 | PHENYLARSINE OXIDE | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4245918 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4250711 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL55 | PENTAMIDINE | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4244022 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL35241 | DIMINAZENE | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4247258 | — | EC50 | = | 133.0 | nM | 6.88 |
| CHEMBL4237349 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4237238 | — | EC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL4240979 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4247810 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4239171 | — | EC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL4090897 | — | EC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL4248268 | — | EC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL4250174 | — | EC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL4237659 | — | EC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL328910 | 2,4-DIHYDROXYBENZOIC ACID | EC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL4251018 | — | EC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL4237726 | — | EC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL4244828 | — | EC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL4068891 | — | EC50 | = | 31800.0 | nM | 4.50 |
| CHEMBL4241091 | — | EC50 | = | 32900.0 | nM | 4.48 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | EC50 | = | 38700.0 | nM | 4.41 |
| CHEMBL4245303 | — | EC50 | = | 42100.0 | nM | 4.38 |
| CHEMBL4069905 | — | EC50 | = | 45700.0 | nM | 4.34 |
| CHEMBL4241528 | — | EC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL4243481 | — | EC50 | = | 400000.0 | nM | - |
| CHEMBL4249095 | — | EC50 | = | 400000.0 | nM | - |
| CHEMBL4241625 | — | EC50 | = | 400000.0 | nM | - |