Assay Detail
Binding
CHEMBL4270091
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Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured MDH refolding after 20 to 40 mins by spectrometric analysis
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Hydroxybiphenylamide GroEL/ES Inhibitors Are Potent Antibacterials against Planktonic and Biofilm Forms of Staphylococcus aureus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 4.86 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1632145 | — | — | 1 | 5.77 |
| CHEMBL12131 | CLOSANTEL | 2.0 | 1 | 5.66 |
| CHEMBL4277733 | — | — | 1 | 5.57 |
| CHEMBL287542 | RAFOXANIDE | 2.0 | 1 | 5.37 |
| CHEMBL4293874 | — | — | 1 | 5.02 |
| CHEMBL1631668 | — | — | 1 | 4.62 |
| CHEMBL4281358 | — | — | 1 | 4.48 |
| CHEMBL4283280 | — | — | 1 | 4.43 |
| CHEMBL4291977 | — | — | 1 | 4.42 |
| CHEMBL4277902 | — | — | 1 | 4.40 |
| CHEMBL4284769 | — | — | 1 | 4.38 |
| CHEMBL1801800 | METABROMSALAN | 4.0 | 1 | 4.21 |
| CHEMBL387675 | DAPTOMYCIN | 4.0 | 1 | - |
| CHEMBL262777 | VANCOMYCIN | 4.0 | 1 | - |
| CHEMBL2046765 | — | — | 1 | - |
| CHEMBL4292831 | — | — | 1 | - |
| CHEMBL4282229 | — | — | 1 | - |
| CHEMBL4286707 | — | — | 1 | - |
| CHEMBL4292443 | — | — | 1 | - |
| CHEMBL4284817 | — | — | 1 | - |
| CHEMBL4281802 | — | — | 1 | - |
| CHEMBL374478 | RIFAMPIN | 4.0 | 1 | - |
| CHEMBL4285476 | — | — | 1 | - |
| CHEMBL4292652 | — | — | 1 | - |
| CHEMBL4282049 | — | — | 1 | - |
| CHEMBL4280410 | — | — | 1 | - |
| CHEMBL4287938 | — | — | 1 | - |
| CHEMBL4282354 | — | — | 1 | - |
| CHEMBL4291342 | — | — | 1 | - |
| CHEMBL4295129 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1632145 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL12131 | CLOSANTEL | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4277733 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL287542 | RAFOXANIDE | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4293874 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL1631668 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4281358 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL4283280 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL4291977 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL4277902 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4284769 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL1801800 | METABROMSALAN | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL4278650 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL115523 | N-PHENYLBENZAMIDE | IC50 | > | 100000.0 | nM | - |
| CHEMBL4285206 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4293036 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL460481 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4286965 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4294873 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL82970 | SALICYLANILIDE | IC50 | > | 100000.0 | nM | - |
| CHEMBL4279725 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4293780 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4283202 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4288844 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4286566 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4282114 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4289991 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4287756 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1559759 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL494463 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4292251 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4281802 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4295129 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4291342 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4282354 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4287938 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4280410 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4282049 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4292652 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4285476 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL374478 | RIFAMPIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL174 | AMPICILLIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL4284817 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4292443 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4286707 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4282229 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4292831 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2046765 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL262777 | VANCOMYCIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL387675 | DAPTOMYCIN | IC50 | > | 100000.0 | nM | - |