Assay Detail
Functional
CHEMBL4272722
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Antitrypanosomal activity against Trypanosoma cruzi Tulahuen strain C2C4 amastigote forms infected in rat L6 cells after 96 hrs by CPRG/Nonidet reagent based photometric method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.17 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329577 | — | — | 1 | 8.70 |
| CHEMBL134980 | — | — | 1 | 7.68 |
| CHEMBL135059 | — | — | 1 | 7.47 |
| CHEMBL315874 | — | — | 1 | 7.46 |
| CHEMBL420248 | — | — | 1 | 7.37 |
| CHEMBL420617 | — | — | 1 | 7.30 |
| CHEMBL414435 | — | — | 1 | 7.24 |
| CHEMBL363162 | — | — | 1 | 7.02 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 5.78 |
| CHEMBL281375 | — | — | 1 | 5.76 |
| CHEMBL4282030 | — | — | 1 | 5.62 |
| CHEMBL21313 | — | — | 1 | 5.53 |
| CHEMBL92305 | — | — | 1 | 5.49 |
| CHEMBL20307 | — | — | 1 | 5.48 |
| CHEMBL283997 | — | — | 1 | 5.43 |
| CHEMBL20649 | — | — | 1 | 5.41 |
| CHEMBL276951 | — | — | 1 | 5.34 |
| CHEMBL278568 | — | — | 1 | 5.21 |
| CHEMBL90796 | — | — | 1 | 5.00 |
| CHEMBL329373 | — | — | 1 | 4.89 |
| CHEMBL93621 | — | — | 1 | 4.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329577 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL134980 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL135059 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL315874 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL420248 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL420617 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL414435 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL363162 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL281375 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL4282030 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL21313 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL92305 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL20307 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL283997 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL20649 | — | IC50 | = | 3910.0 | nM | 5.41 |
| CHEMBL276951 | — | IC50 | = | 4530.0 | nM | 5.34 |
| CHEMBL278568 | — | IC50 | = | 6140.0 | nM | 5.21 |
| CHEMBL90796 | — | IC50 | = | 10040.0 | nM | 5.00 |
| CHEMBL329373 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL93621 | — | IC50 | = | 32630.0 | nM | 4.49 |