Assay Detail
Functional
CHEMBL4310792
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Anti-parasitic activity against type 1 nitroreductase over-expressing Trypanosoma brucei
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Thiazole, thio and semicarbazone derivatives against tropical infective diseases: Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.22 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1872946 | NITHIAMIDE | 2.0 | 1 | 6.24 |
| CHEMBL1330029 | — | — | 1 | 6.24 |
| CHEMBL4585999 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1872946 | NITHIAMIDE | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL1330029 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4585999 | — | IC50 | = | 640.0 | nM | 6.19 |