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Compound Detail

CHEMBL1330029

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CCCCC(=O)Nc1ncc([N+](=O)[O-])s1

Basic Information

ChEMBL ID CHEMBL1330029
Phase Preclinical
Structure Type MOL
InChI Key HAQCGFVINUGJBS-UHFFFAOYSA-N
4
Targets
7
Activities
2
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

229.3
MW (Da)
2.18
ALogP
5
HBA
1
HBD
85.1
PSA (Ų)
0.62
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C8H11N3O3S
MW 229.26
Aromatic Rings 1
Heavy Atoms 15
NP-Likeness -2.27

Activity Summary

IC50 6 meas. best 6.52
EC50 1 meas. best 6.85

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
EC50 6.85 6.85 141.0 1
Trichomonas vaginalis
CHEMBL612884
IC50 6.52 6.51 305.0 2
Giardia intestinalis
CHEMBL612652
IC50 6.4 6.4 398.0 2
Trypanosoma brucei
CHEMBL612849
IC50 6.24 5.805 570.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
24529307 10.1016/j.bmc.2014.01.029 Giardia intestinalis 3
24529307 10.1016/j.bmc.2014.01.029 Trichomonas vaginalis 2
30453246 10.1016/j.ejmech.2018.11.013 Trypanosoma brucei 2
30453246 10.1016/j.ejmech.2018.11.013 Unchecked 2
24529307 10.1016/j.bmc.2014.01.029 Vero 1
24529307 10.1016/j.bmc.2014.01.029 Trypanosoma cruzi 1
24529307 10.1016/j.bmc.2014.01.029 Leishmania amazonensis 1

Data from ChEMBL 36 via Core Engine