Assay Detail
Functional
CHEMBL4313829
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against intracellular amastigote stage of Trypanosoma cruzi Silvio X10/1 infected in human U2OS cells measured after 96 hrs by DRAQ5 dye based microscopic analysis
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.97 | 6.52 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4464312 | — | — | 1 | 6.52 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 5.41 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4464312 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL110 | BENZNIDAZOLE | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL125 | MILTEFOSINE | Inhibition | - | % | - |