Assay Detail
Functional
CHEMBL4313833
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma cruzi strain Y trypomastigotes infected in human HG39 cells by TaqMan probe based RT-PCR analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.21 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 5.62 |
| CHEMBL4464312 | — | — | 1 | 5.12 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110 | BENZNIDAZOLE | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4464312 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL125 | MILTEFOSINE | EC50 | = | 12500.0 | nM | 4.90 |