Assay Detail
Functional
CHEMBL4313834
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against intracellular amastigote stage of Trypanosoma cruzi ARMA 13 cl1 infected in human U2OS cells measured after 96 hrs by DRAQ5 dye based microscopic analysis
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.61 | 5.92 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4464312 | — | — | 1 | 5.92 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 5.29 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4464312 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL110 | BENZNIDAZOLE | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL125 | MILTEFOSINE | Inhibition | - | % | - |