Assay Detail
Binding
CHEMBL4330409
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Inhibition of TIE2 (unknown origin) after 4 hrs by ADP-Glo reagent based luminescent assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel anti-angiogenesis agents. Part 10: Multi-target inhibitors of VEGFR-2, Tie-2 and EphB4 incorporated with 1,2,3-triazol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 8.74 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4449700 | — | — | 1 | 9.59 |
| CHEMBL4447552 | — | — | 1 | 9.55 |
| CHEMBL4528844 | — | — | 1 | 9.52 |
| CHEMBL4452256 | — | — | 1 | 9.44 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 9.41 |
| CHEMBL4570075 | — | — | 1 | 9.35 |
| CHEMBL4441465 | — | — | 1 | 9.14 |
| CHEMBL4556134 | — | — | 1 | 7.62 |
| CHEMBL4454065 | — | — | 1 | 7.21 |
| CHEMBL4456856 | — | — | 1 | 6.58 |
| CHEMBL4556899 | — | — | 1 | - |
| CHEMBL4473253 | — | — | 1 | - |
| CHEMBL4470400 | — | — | 1 | - |
| CHEMBL4519953 | — | — | 1 | - |
| CHEMBL4449321 | — | — | 1 | - |
| CHEMBL4443204 | — | — | 1 | - |
| CHEMBL4440813 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4449700 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL4447552 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL4528844 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4452256 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL4570075 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL4441465 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL4556134 | — | IC50 | = | 24.19 | nM | 7.62 |
| CHEMBL4454065 | — | IC50 | = | 61.26 | nM | 7.21 |
| CHEMBL4456856 | — | IC50 | = | 265.72 | nM | 6.58 |
| CHEMBL4556899 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4473253 | — | IC50 | - | — | - | |
| CHEMBL4470400 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4519953 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4449321 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4443204 | — | IC50 | - | — | - | |
| CHEMBL4440813 | — | IC50 | - | — | - |