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Assay Detail

CHEMBL4330418

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anti-angiogenic activity against human EAhy926 after 24 hrs by CCK-8 assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type EA.hy 926
Confidence 1 — Organism
Curated By Autocuration

Target

EA.hy 926 (CHEMBL4296410)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of novel anti-angiogenesis agents. Part 10: Multi-target inhibitors of VEGFR-2, Tie-2 and EphB4 incorporated with 1,2,3-triazol.
Pan X, Liang L, Si R, Wang J, Zhang Q, Zhou H, Zhang L, Zhang J.
Eur J Med Chem (2019) 163 : 1 -9
PubMed 30503935 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 4.84 5.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4519953 1 5.19
CHEMBL4454065 1 5.03
CHEMBL1336 SORAFENIB 4.0 1 4.93
CHEMBL4556134 1 4.92
CHEMBL4441465 1 4.84
CHEMBL4456856 1 4.61
CHEMBL4556899 1 4.36
CHEMBL4440813 1 -
CHEMBL4470400 1 -
CHEMBL4449700 1 -
CHEMBL4528844 1 -
CHEMBL4473253 1 -
CHEMBL4452256 1 -
CHEMBL4570075 1 -
CHEMBL4449321 1 -
CHEMBL4443204 1 -
CHEMBL4447552 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4519953 IC50 = 6490.0 nM 5.19
CHEMBL4454065 IC50 = 9280.0 nM 5.03
CHEMBL1336 SORAFENIB IC50 = 11740.0 nM 4.93
CHEMBL4556134 IC50 = 12090.0 nM 4.92
CHEMBL4441465 IC50 = 14490.0 nM 4.84
CHEMBL4456856 IC50 = 24310.0 nM 4.61
CHEMBL4556899 IC50 = 43940.0 nM 4.36
CHEMBL4440813 IC50 = 708140.0 nM -
CHEMBL4470400 IC50 = 110170.0 nM -
CHEMBL4449700 IC50 = 677690.0 nM -
CHEMBL4528844 IC50 = 121970.0 nM -
CHEMBL4473253 IC50 - -
CHEMBL4452256 IC50 = 439890.0 nM -
CHEMBL4570075 IC50 = 134150.0 nM -
CHEMBL4449321 IC50 = 170470.0 nM -
CHEMBL4443204 IC50 = 136530.0 nM -
CHEMBL4447552 IC50 = 431190.0 nM -