Assay Detail
Functional
CHEMBL4333751
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against beta-galactosidase expressing nifurtimox-sensitive Trypanosoma cruzi Tulahuen CL2 infected in human MRC5 SV2 cells assessed as reduction in parasite burden after 168 hrs by CPRG and Nonidet based spectrophotometric analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antimicrobial activities of N<sup>6</sup>-hydroxyagelasine analogs and revision of the structure of ageloximes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.77 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4469221 | — | — | 1 | 6.28 |
| CHEMBL4592498 | — | — | 1 | 6.27 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 5.57 |
| CHEMBL4443174 | — | — | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4469221 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4592498 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 2690.0 | nM | 5.57 |
| CHEMBL4443174 | — | IC50 | = | 11500.0 | nM | 4.94 |