Assay Detail
ADMET
CHEMBL4338317
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Cytotoxicity against human THP1 cells assessed as reduction in cell viability after 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Pharmacological Studies of 4-Hydroxyphenyl-Derived Phosphonium Salts Active in a Mouse Model of Visceral Leishmaniasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.33 | 5.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4250711 | — | — | 1 | 5.74 |
| CHEMBL4449078 | — | — | 1 | 5.68 |
| CHEMBL4472812 | — | — | 1 | 5.63 |
| CHEMBL4540674 | — | — | 1 | 5.61 |
| CHEMBL4455204 | — | — | 1 | 5.55 |
| CHEMBL4098620 | — | — | 1 | 5.52 |
| CHEMBL4514901 | — | — | 1 | 5.52 |
| CHEMBL4518264 | — | — | 1 | 4.89 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 4.58 |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4250711 | — | EC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL4449078 | — | EC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL4472812 | — | EC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL4540674 | — | EC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL4455204 | — | EC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL4098620 | — | EC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL4514901 | — | EC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL4518264 | — | EC50 | = | 12850.0 | nM | 4.89 |
| CHEMBL125 | MILTEFOSINE | EC50 | = | 26250.0 | nM | 4.58 |
| CHEMBL267345 | AMPHOTERICIN B | EC50 | = | 27850.0 | nM | 4.55 |