Assay Detail
Binding
CHEMBL4340216
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Inhibition of pH 6.25-stimulated mouse ASIC1a/2a heterodimer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Identification of Isoform 2 Acid-Sensing Ion Channel Inhibitors as Tool Compounds for Target Validation Studies in CNS.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.83 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4445209 | — | — | 1 | 5.07 |
| CHEMBL4518161 | — | — | 1 | 4.96 |
| CHEMBL4528810 | — | — | 1 | 4.95 |
| CHEMBL35241 | DIMINAZENE | 2.0 | 1 | 4.34 |
| CHEMBL4456021 | — | — | 1 | - |
| CHEMBL4590631 | — | — | 1 | - |
| CHEMBL4538655 | — | — | 1 | - |
| CHEMBL4469611 | — | — | 1 | - |
| CHEMBL4476781 | — | — | 1 | - |
| CHEMBL4593063 | — | — | 1 | - |
| CHEMBL4446500 | — | — | 1 | - |
| CHEMBL4591499 | — | — | 1 | - |
| CHEMBL4593172 | — | — | 1 | - |
| CHEMBL4524195 | — | — | 1 | - |
| CHEMBL4555958 | — | — | 1 | - |
| CHEMBL4462808 | — | — | 1 | - |
| CHEMBL4450681 | — | — | 1 | - |
| CHEMBL4587871 | — | — | 1 | - |
| CHEMBL4440380 | — | — | 1 | - |
| CHEMBL4463485 | — | — | 1 | - |
| CHEMBL4517411 | — | — | 1 | - |
| CHEMBL4442568 | — | — | 1 | - |
| CHEMBL4463769 | — | — | 1 | - |
| CHEMBL4527919 | — | — | 1 | - |
| CHEMBL4440787 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4445209 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL4518161 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL4528810 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL35241 | DIMINAZENE | IC50 | = | 45200.0 | nM | 4.34 |
| CHEMBL4456021 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4590631 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4538655 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4469611 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4476781 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4593063 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4446500 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4591499 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4593172 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4524195 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4555958 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4462808 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4450681 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4587871 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4440380 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4463485 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4517411 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4442568 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4463769 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4527919 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4440787 | — | IC50 | > | 30000.0 | nM | - |