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Assay Detail

CHEMBL4356744

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human SUDHL1 cells assessed as reduction in cell viability incubated for 4 days by cell-titer glo luminescent assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SU-DHL-1
Confidence 1 — Organism
Curated By Autocuration

Target

SU-DHL-1 (CHEMBL2366200)
Type CELL-LINE
Organism Homo sapiens

Publication

Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein.
Zhou H, Bai L, Xu R, Zhao Y, Chen J, McEachern D, Chinnaswamy K, Wen B, Dai L, Kumar P, Yang CY, Liu Z, Wang M, Liu L, Meagher JL, Yi H, Sun D, Stuckey JA, Wang S.
J Med Chem (2019) 62 : 11280 -11300
PubMed 31747516 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 5.92 6.37

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4452301 1 6.37
CHEMBL4452527 1 6.21
CHEMBL4462015 1 5.62
CHEMBL4561959 1 5.49
CHEMBL4462902 1 -
CHEMBL4552403 1 -
CHEMBL4541088 1 -
CHEMBL4469975 1 -
CHEMBL4460570 1 -
CHEMBL4458633 1 -
CHEMBL4593217 1 -
CHEMBL4589874 1 -
CHEMBL4575382 1 -
CHEMBL4451225 1 -
CHEMBL4546818 1 -
CHEMBL4592058 1 -
CHEMBL4443577 1 -
CHEMBL4567496 1 -
CHEMBL4585187 1 -
CHEMBL4476035 1 -
CHEMBL4531706 1 -
CHEMBL4465803 1 -
CHEMBL4513915 1 -
CHEMBL4532980 1 -
CHEMBL4455300 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4452301 IC50 = 430.0 nM 6.37
CHEMBL4452527 IC50 = 610.0 nM 6.21
CHEMBL4462015 IC50 = 2370.0 nM 5.62
CHEMBL4561959 IC50 = 3240.0 nM 5.49
CHEMBL4462902 IC50 - -
CHEMBL4552403 IC50 - -
CHEMBL4541088 IC50 - -
CHEMBL4469975 IC50 - -
CHEMBL4460570 IC50 > 10000.0 nM -
CHEMBL4458633 IC50 - -
CHEMBL4593217 IC50 - -
CHEMBL4589874 IC50 - -
CHEMBL4575382 IC50 > 10000.0 nM -
CHEMBL4451225 IC50 - -
CHEMBL4546818 IC50 - -
CHEMBL4592058 IC50 - -
CHEMBL4443577 IC50 > 10000.0 nM -
CHEMBL4567496 IC50 - -
CHEMBL4585187 IC50 - -
CHEMBL4476035 IC50 > 10000.0 nM -
CHEMBL4531706 IC50 - -
CHEMBL4465803 IC50 - -
CHEMBL4513915 IC50 > 10000.0 nM -
CHEMBL4532980 IC50 > 10000.0 nM -
CHEMBL4455300 IC50 - -