Assay Detail
Functional
CHEMBL4384182
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Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel 1-phenyl phenanthridin-6(5H)-one derivatives as anti-tumor agents targeting TOPK.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 6.61 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4436998 | — | — | 1 | 8.10 |
| CHEMBL4537262 | — | — | 1 | 7.72 |
| CHEMBL4537653 | — | — | 1 | 7.35 |
| CHEMBL3672369 | — | — | 1 | 7.35 |
| CHEMBL4458873 | — | — | 1 | 7.12 |
| CHEMBL4474776 | — | — | 1 | 6.99 |
| CHEMBL4445123 | — | — | 1 | 6.94 |
| CHEMBL4519328 | — | — | 1 | 6.85 |
| CHEMBL4452595 | — | — | 1 | 6.81 |
| CHEMBL4551832 | — | — | 1 | 6.67 |
| CHEMBL4458265 | — | — | 1 | 6.64 |
| CHEMBL4535960 | — | — | 1 | 6.62 |
| CHEMBL4455498 | — | — | 1 | 6.56 |
| CHEMBL4444190 | — | — | 1 | 6.52 |
| CHEMBL4451419 | — | — | 1 | 6.50 |
| CHEMBL4536593 | — | — | 1 | 6.45 |
| CHEMBL4579248 | — | — | 1 | 6.43 |
| CHEMBL4452726 | — | — | 1 | 6.42 |
| CHEMBL4469640 | — | — | 1 | 6.41 |
| CHEMBL4562809 | — | — | 1 | 6.40 |
| CHEMBL4458314 | — | — | 1 | 6.38 |
| CHEMBL4534841 | — | — | 1 | 6.36 |
| CHEMBL3672271 | — | — | 1 | 6.33 |
| CHEMBL4442377 | — | — | 1 | 6.33 |
| CHEMBL4555026 | — | — | 1 | 6.27 |
| CHEMBL4439067 | — | — | 1 | 6.25 |
| CHEMBL4467180 | — | — | 1 | 6.24 |
| CHEMBL4564624 | — | — | 1 | 6.20 |
| CHEMBL4535216 | — | — | 1 | 6.14 |
| CHEMBL4585042 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4436998 | — | IC50 | = | 7.867 | nM | 8.10 |
| CHEMBL4537262 | — | IC50 | = | 18.89 | nM | 7.72 |
| CHEMBL3672369 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4537653 | — | IC50 | = | 44.73 | nM | 7.35 |
| CHEMBL4458873 | — | IC50 | = | 75.85 | nM | 7.12 |
| CHEMBL4474776 | — | IC50 | = | 102.4 | nM | 6.99 |
| CHEMBL4445123 | — | IC50 | = | 114.2 | nM | 6.94 |
| CHEMBL4519328 | — | IC50 | = | 141.2 | nM | 6.85 |
| CHEMBL4452595 | — | IC50 | = | 156.1 | nM | 6.81 |
| CHEMBL4551832 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL4458265 | — | IC50 | = | 231.2 | nM | 6.64 |
| CHEMBL4535960 | — | IC50 | = | 242.2 | nM | 6.62 |
| CHEMBL4455498 | — | IC50 | = | 273.7 | nM | 6.56 |
| CHEMBL4444190 | — | IC50 | = | 299.3 | nM | 6.52 |
| CHEMBL4451419 | — | IC50 | = | 314.1 | nM | 6.50 |
| CHEMBL4536593 | — | IC50 | = | 357.0 | nM | 6.45 |
| CHEMBL4579248 | — | IC50 | = | 371.7 | nM | 6.43 |
| CHEMBL4452726 | — | IC50 | = | 384.8 | nM | 6.42 |
| CHEMBL4469640 | — | IC50 | = | 385.2 | nM | 6.41 |
| CHEMBL4562809 | — | IC50 | = | 396.5 | nM | 6.40 |
| CHEMBL4458314 | — | IC50 | = | 419.2 | nM | 6.38 |
| CHEMBL4534841 | — | IC50 | = | 438.0 | nM | 6.36 |
| CHEMBL3672271 | — | IC50 | = | 468.0 | nM | 6.33 |
| CHEMBL4442377 | — | IC50 | = | 469.0 | nM | 6.33 |
| CHEMBL4555026 | — | IC50 | = | 534.3 | nM | 6.27 |
| CHEMBL4439067 | — | IC50 | = | 563.7 | nM | 6.25 |
| CHEMBL4467180 | — | IC50 | = | 571.0 | nM | 6.24 |
| CHEMBL4564624 | — | IC50 | = | 636.0 | nM | 6.20 |
| CHEMBL4535216 | — | IC50 | = | 719.9 | nM | 6.14 |
| CHEMBL4585042 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4591205 | — | IC50 | = | 962.0 | nM | 6.02 |
| CHEMBL4455728 | — | IC50 | = | 949.9 | nM | 6.02 |
| CHEMBL4440222 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4438486 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4534499 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4588267 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4528387 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4517435 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4473141 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4552688 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4573944 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4527920 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4469535 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4439624 | — | IC50 | > | 1000.0 | nM | - |