Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4385510

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma brucei BF427 after 48 hrs by Alamar Blue assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei (CHEMBL612849)
Type ORGANISM
Organism Trypanosoma brucei

Publication

Triazolopyrimidines and Imidazopyridines: Structure-Activity Relationships and in Vivo Efficacy for Trypanosomiasis.
Nagendar P, Gillespie JR, Herbst ZM, Ranade RM, Molasky NMR, Faghih O, Turner RM, Gelb MH, Buckner FS.
ACS Med Chem Lett (2019) 10 : 105 -110
PubMed 30655955 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 31 7.69 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3115821 1 8.40
CHEMBL4453457 1 8.29
CHEMBL4474963 1 8.19
CHEMBL4439495 1 8.17
CHEMBL4476328 1 8.11
CHEMBL4528823 1 8.10
CHEMBL4445085 1 8.08
CHEMBL4439991 1 8.04
CHEMBL4472529 1 8.00
CHEMBL4544915 1 8.00
CHEMBL4526277 1 7.96
CHEMBL4544608 1 7.94
CHEMBL4476581 1 7.92
CHEMBL4446298 1 7.85
CHEMBL4541614 1 7.78
CHEMBL4578911 1 7.77
CHEMBL4569396 1 7.77
CHEMBL4455233 1 7.75
CHEMBL4450726 1 7.73
CHEMBL4530295 1 7.70
CHEMBL4476835 1 7.68
CHEMBL4571231 1 7.62
CHEMBL4454106 1 7.50
CHEMBL4515207 1 7.45
CHEMBL4436425 1 7.41
CHEMBL4578045 1 7.29
CHEMBL4462886 1 7.28
CHEMBL4538498 1 7.08
CHEMBL4580042 1 6.78
CHEMBL4521915 1 6.78

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3115821 EC50 = 4.0 nM 8.40
CHEMBL4453457 EC50 = 5.1 nM 8.29
CHEMBL4474963 EC50 = 6.5 nM 8.19
CHEMBL4439495 EC50 = 6.7 nM 8.17
CHEMBL4476328 EC50 = 7.8 nM 8.11
CHEMBL4528823 EC50 = 8.0 nM 8.10
CHEMBL4445085 EC50 = 8.4 nM 8.08
CHEMBL4439991 EC50 = 9.1 nM 8.04
CHEMBL4472529 EC50 = 10.0 nM 8.00
CHEMBL4544915 EC50 = 9.9 nM 8.00
CHEMBL4526277 EC50 = 11.0 nM 7.96
CHEMBL4544608 EC50 = 11.4 nM 7.94
CHEMBL4476581 EC50 = 12.0 nM 7.92
CHEMBL4446298 EC50 = 14.0 nM 7.85
CHEMBL4541614 EC50 = 16.6 nM 7.78
CHEMBL4578911 EC50 = 17.0 nM 7.77
CHEMBL4569396 EC50 = 17.0 nM 7.77
CHEMBL4455233 EC50 = 18.0 nM 7.75
CHEMBL4450726 EC50 = 18.7 nM 7.73
CHEMBL4530295 EC50 = 20.0 nM 7.70
CHEMBL4476835 EC50 = 20.8 nM 7.68
CHEMBL4571231 EC50 = 24.0 nM 7.62
CHEMBL4454106 EC50 = 32.0 nM 7.50
CHEMBL4515207 EC50 = 35.8 nM 7.45
CHEMBL4436425 EC50 = 39.2 nM 7.41
CHEMBL4578045 EC50 = 50.8 nM 7.29
CHEMBL4462886 EC50 = 53.0 nM 7.28
CHEMBL4538498 EC50 = 82.8 nM 7.08
CHEMBL4580042 EC50 = 165.0 nM 6.78
CHEMBL4521915 EC50 = 166.0 nM 6.78
CHEMBL55 PENTAMIDINE EC50 = 1420.0 nM 5.85