Compound Detail
CHEMBL4569396
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Basic Information
| ChEMBL ID | CHEMBL4569396 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FEEQJBKFXCSKGT-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
4
PK Parameters
5
Publications
0
Known Names
Molecular Properties
437.4
MW (Da)
5.34
ALogP
3
HBA
2
HBD
73.9
PSA (Ų)
0.45
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma brucei CHEMBL612849 | EC50 | 7.77 | 7.77 | 17.0 | 1 |
| Trypanosoma cruzi CHEMBL368 | EC50 | 7.6 | 7.6 | 25.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 12029.33 | ng.hr.mL-1 | Mus musculus |
| Cmax | 6670.0 | nM | Mus musculus |
| T1/2 | 0.2817 | hr | Homo sapiens |
| T1/2 | 0.08 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Trypanosoma brucei | EC50 | = | 17.0 | nM | 7.77 | Antitrypanosomal activity against Trypanosoma brucei BF427 after 48 hrs by Alama... | 30655955 |
| Trypanosoma cruzi | EC50 | = | 25.0 | nM | 7.6 | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen amastigotes infecte... | 30655955 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30655955 | 10.1021/acsmedchemlett.8b00498 | ADMET | 5 |
| 30655955 | 10.1021/acsmedchemlett.8b00498 | Trypanosoma cruzi | 1 |
| 30655955 | 10.1021/acsmedchemlett.8b00498 | Trypanosoma brucei | 1 |
| 30655955 | 10.1021/acsmedchemlett.8b00498 | Unchecked | 1 |
| 30655955 | 10.1021/acsmedchemlett.8b00498 | HepG2 | 1 |
Data from ChEMBL 36 via Core Engine