Assay Detail
Binding
CHEMBL4392933
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Rosetta(DE3) assessed as reduction in HSP60/HSP10-mediated denatured MDH refolding by measuring MDH enzyme activity using sodium mesoxalate as substrate after 40 to 60 mins by malachite green dye based spectrometric analysis
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 58 | 5.14 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1200712 | EVANS BLUE | 4.0 | 1 | 6.77 |
| CHEMBL1516388 | — | — | 1 | 5.92 |
| CHEMBL496 | HEXACHLOROPHENE | 4.0 | 1 | 5.89 |
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | 5.68 |
| CHEMBL1265 | ADAPALENE | 4.0 | 1 | 5.64 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 5.64 |
| CHEMBL290106 | BITHIONOL | 4.0 | 1 | 5.55 |
| CHEMBL12131 | CLOSANTEL | 2.0 | 1 | 5.55 |
| CHEMBL5483017 | — | — | 1 | 5.54 |
| CHEMBL220190 | ASCORBYL PALMITATE | -1.0 | 1 | 5.51 |
| CHEMBL275938 | AURINTRICARBOXYLIC ACID | — | 1 | 5.50 |
| CHEMBL1360563 | HEMATEIN | — | 1 | 5.44 |
| CHEMBL506247 | TANNIC ACID | 4.0 | 1 | 5.42 |
| CHEMBL78764 | — | — | 1 | 5.40 |
| CHEMBL15594 | ARACHIDONIC ACID | -1.0 | 1 | 5.35 |
| CHEMBL1325592 | PROTOPORPHYRIN | -1.0 | 1 | 5.31 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 5.28 |
| CHEMBL64894 | GENTIAN VIOLET | 4.0 | 1 | 5.24 |
| CHEMBL2003538 | CETYLPYRIDINIUM CHLORIDE | 3.0 | 1 | 5.22 |
| CHEMBL295316 | PLUMBAGIN | 1.0 | 1 | 5.20 |
| CHEMBL4448756 | — | — | 1 | 5.17 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 5.14 |
| CHEMBL5314343 | — | — | 1 | 5.13 |
| CHEMBL253570 | GOSSYPETIN | — | 1 | 5.12 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.08 |
| CHEMBL456 | ETHACRYNIC ACID | 4.0 | 1 | 5.07 |
| CHEMBL388590 | BENZBROMARONE | 4.0 | 1 | 5.04 |
| CHEMBL153062 | 4-NONYLPHENOL | — | 1 | 5.02 |
| CHEMBL1478 | LITHOCHOLIC ACID | — | 1 | 5.00 |
| CHEMBL28626 | MORIN | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1200712 | EVANS BLUE | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1516388 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL496 | HEXACHLOROPHENE | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL15192 | LAPACHONE | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1265 | ADAPALENE | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL290106 | BITHIONOL | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL12131 | CLOSANTEL | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5483017 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL220190 | ASCORBYL PALMITATE | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL275938 | AURINTRICARBOXYLIC ACID | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1360563 | HEMATEIN | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL506247 | TANNIC ACID | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL78764 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL15594 | ARACHIDONIC ACID | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1325592 | PROTOPORPHYRIN | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL38 | TRETINOIN | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL64894 | GENTIAN VIOLET | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL2003538 | CETYLPYRIDINIUM CHLORIDE | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL295316 | PLUMBAGIN | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4448756 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL265502 | SURAMIN | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL5314343 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL253570 | GOSSYPETIN | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL140 | CURCUMIN | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL456 | ETHACRYNIC ACID | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL388590 | BENZBROMARONE | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL153062 | 4-NONYLPHENOL | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL1478 | LITHOCHOLIC ACID | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL28626 | MORIN | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1042 | CHOLECALCIFEROL | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL704 | MESALAMINE | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1236460 | THIOSTREPTON | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL590 | MENADIONE | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1630577 | ABAMECTIN COMPONENT B1A | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL6067487 | IVERMECTIN | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL34398 | 4'-METHOXYCHALCONE | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL33845 | DICHLOROPHEN | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1879202 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL276473 | 4'-HYDROXYCHALCONE | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL7747 | 4-HYDROXYCHALCONE | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL294264 | PURPURIN | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL221753 | BENZETHONIUM CHLORIDE | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL1536 | ERGOCALCIFEROL | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL1200787 | PHENOXYBENZAMINE HYDROCHLORIDE | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL3989697 | RIBOFLAVIN 5'-PHOSPHATE SODIUM | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL506 | PRIMAQUINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL428647 | PACLITAXEL | IC50 | > | 100000.0 | nM | - |
| CHEMBL284328 | HOMIDIUM BROMIDE | IC50 | > | 100000.0 | nM | - |
| CHEMBL550495 | METHYLENE BLUE | IC50 | > | 100000.0 | nM | - |