Assay Detail
Functional
CHEMBL4415678
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma cruzi Tulahuen CL2 amastigotes infected in human MRC5 SV2 cells incubated for 7 days by chlorophenol red beta-D-galactopyranoside substrate based spectrophotometric assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Pyrrolo[2,3-<i>b</i>]pyridine (1,7-Dideazapurine) Nucleoside Analogues as Anti-<i>Trypanosoma cruzi</i> Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 5.82 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4446605 | — | — | 1 | 7.40 |
| CHEMBL4473879 | — | — | 1 | 7.10 |
| CHEMBL4549946 | — | — | 1 | 6.72 |
| CHEMBL4473990 | — | — | 1 | 6.70 |
| CHEMBL99203 | IODOTUBERCIDIN | — | 1 | 6.10 |
| CHEMBL4469010 | — | — | 1 | 6.09 |
| CHEMBL4438771 | — | — | 1 | 5.94 |
| CHEMBL4452959 | — | — | 1 | 5.81 |
| CHEMBL4471091 | — | — | 1 | 5.76 |
| CHEMBL4572925 | — | — | 1 | 5.67 |
| CHEMBL4436060 | — | — | 1 | 5.64 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 5.63 |
| CHEMBL4458931 | — | — | 1 | 5.40 |
| CHEMBL4536538 | — | — | 1 | 5.10 |
| CHEMBL4594063 | — | — | 1 | 5.06 |
| CHEMBL4465961 | — | — | 1 | 4.43 |
| CHEMBL4454812 | — | — | 1 | 4.32 |
| CHEMBL4513828 | — | — | 1 | - |
| CHEMBL4537664 | — | — | 1 | - |
| CHEMBL4454616 | — | — | 1 | - |
| CHEMBL4555076 | — | — | 1 | - |
| CHEMBL4555901 | — | — | 1 | - |
| CHEMBL4461218 | — | — | 1 | - |
| CHEMBL4445154 | — | — | 1 | - |
| CHEMBL4434960 | — | — | 1 | - |
| CHEMBL4437328 | — | — | 1 | - |
| CHEMBL4464097 | — | — | 1 | - |
| CHEMBL4461544 | — | — | 1 | - |
| CHEMBL4472192 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4446605 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4473879 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4549946 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4473990 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL99203 | IODOTUBERCIDIN | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4469010 | — | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4438771 | — | EC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL4452959 | — | EC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL4471091 | — | EC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL4572925 | — | EC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL4436060 | — | EC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL110 | BENZNIDAZOLE | EC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL4458931 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4536538 | — | EC50 | = | 7980.0 | nM | 5.10 |
| CHEMBL4594063 | — | EC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4465961 | — | EC50 | = | 36900.0 | nM | 4.43 |
| CHEMBL4454812 | — | EC50 | = | 47700.0 | nM | 4.32 |
| CHEMBL4513828 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4537664 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4454616 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4555076 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4555901 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4461218 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4445154 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4434960 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4437328 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4464097 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4461544 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4472192 | — | EC50 | > | 64000.0 | nM | - |