Assay Detail
Functional
CHEMBL4415730
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Antitrypanosomal activity against bloodstream form of Trypanosoma cruzi Y trypomastigotes measured after 24 hrs by Neubauer chamber-based light microscopic analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Pyrrolo[2,3-<i>b</i>]pyridine (1,7-Dideazapurine) Nucleoside Analogues as Anti-<i>Trypanosoma cruzi</i> Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 4.69 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 5.24 |
| CHEMBL4471091 | — | — | 1 | 4.44 |
| CHEMBL4473879 | — | — | 1 | 4.39 |
| CHEMBL4549946 | — | — | 1 | - |
| CHEMBL4446605 | — | — | 1 | - |
| CHEMBL4438771 | — | — | 1 | - |
| CHEMBL4469010 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110 | BENZNIDAZOLE | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4471091 | — | EC50 | = | 36300.0 | nM | 4.44 |
| CHEMBL4473879 | — | EC50 | = | 40500.0 | nM | 4.39 |
| CHEMBL4549946 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4446605 | — | EC50 | > | 70000.0 | nM | - |
| CHEMBL4438771 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4469010 | — | EC50 | > | 50000.0 | nM | - |