Assay Detail
Binding
CHEMBL4422542
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Inhibition of GST-fused human Eya2 ED (253 to 538 residues) expressed in Escherichia coli pre-incubated for 10 mins followed by OMFP substrate addition and further incubated for 30 mins by fluorescence based assay
21
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of eya2
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.90 | 5.75 |
| Inhibition | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4463681 | — | — | 1 | 5.75 |
| CHEMBL3191598 | — | — | 1 | 5.64 |
| CHEMBL4459891 | — | — | 1 | 5.46 |
| CHEMBL4530754 | — | — | 2 | 5.40 |
| CHEMBL1975051 | — | — | 1 | 5.14 |
| CHEMBL3195222 | — | — | 1 | 4.75 |
| CHEMBL4445513 | — | — | 1 | 4.75 |
| CHEMBL3189517 | — | — | 1 | 4.54 |
| CHEMBL858 | EDETIC ACID | 3.0 | 1 | 4.19 |
| CHEMBL3190554 | — | — | 1 | 4.14 |
| CHEMBL4446792 | — | — | 1 | 4.10 |
| CHEMBL4458563 | — | — | 1 | - |
| CHEMBL4476815 | — | — | 1 | - |
| CHEMBL4532983 | — | — | 1 | - |
| CHEMBL4446652 | — | — | 1 | - |
| CHEMBL87223 | AMINOQUINURIDE | 2.0 | 1 | - |
| CHEMBL4449839 | — | — | 1 | - |
| CHEMBL1232903 | GLYCERYLPHOSPHATE | — | 1 | - |
| CHEMBL1528 | SODIUM FLUORIDE | 4.0 | 1 | - |
| CHEMBL179166 | SODIUM ORTHOVANAD | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4463681 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3191598 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4459891 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL4530754 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1975051 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL3195222 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4445513 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3189517 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL858 | EDETIC ACID | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL3190554 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL4446792 | — | IC50 | = | 79110.0 | nM | 4.10 |
| CHEMBL179166 | SODIUM ORTHOVANAD | IC50 | = | 1800000.0 | nM | - |
| CHEMBL1528 | SODIUM FLUORIDE | IC50 | = | 6600000.0 | nM | - |
| CHEMBL1232903 | GLYCERYLPHOSPHATE | IC50 | = | 8200000.0 | nM | - |
| CHEMBL4449839 | — | IC50 | = | 11300000.0 | nM | - |
| CHEMBL4446652 | — | Inhibition | - | % | - | |
| CHEMBL4476815 | — | Inhibition | - | % | - | |
| CHEMBL4458563 | — | IC50 | < | 35000.0 | nM | - |
| CHEMBL4532983 | — | IC50 | < | 35000.0 | nM | - |
| CHEMBL87223 | AMINOQUINURIDE | IC50 | < | 35000.0 | nM | - |
| CHEMBL4530754 | — | Inhibition | - | % | - |