Compound Detail
CHEMBL4446792
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Basic Information
| ChEMBL ID | CHEMBL4446792 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VHFWBLODEIFAPB-CIAFOILYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
367.4
MW (Da)
3.66
ALogP
6
HBA
1
HBD
76.7
PSA (Ų)
0.51
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.78
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Eyes absent homolog 2 CHEMBL1293275 | IC50 | 4.78 | 4.44 | 16800.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Eyes absent homolog 2 | IC50 | = | 16800.0 | nM | 4.78 | Inhibition of GST-fused human Eya2 ED (253 to 538 residues) expressed in Escheri... | - |
| Eyes absent homolog 2 | IC50 | = | 79110.0 | nM | 4.1 | Inhibition of GST-fused human Eya2 ED (253 to 538 residues) expressed in Escheri... | - |
Data from ChEMBL 36 via Core Engine