Assay Detail
Functional
CHEMBL4424079
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Antitrypanosomal activity against pentamidine/diminazene/melaminophenyl arsenical resistant Trypanosoma brucei B48 after 48 hrs by alamar blue assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Revisiting tubercidin against kinetoplastid parasites: Aromatic substitutions at position 7 improve activity and reduce toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.87 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4581647 | — | — | 1 | 6.57 |
| CHEMBL2111043 | ISOMETAMIDIUM | 2.0 | 1 | 6.25 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 6.00 |
| CHEMBL267099 | TUBERCIDIN | — | 1 | 5.37 |
| CHEMBL35241 | DIMINAZENE | 2.0 | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4581647 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL2111043 | ISOMETAMIDIUM | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL55 | PENTAMIDINE | EC50 | = | 990.0 | nM | 6.00 |
| CHEMBL267099 | TUBERCIDIN | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL35241 | DIMINAZENE | EC50 | = | 7200.0 | nM | 5.14 |