Assay Detail
Functional
CHEMBL4431996
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei brucei Lister 427 bloodstream forms after 72 hrs by resazurin-based assay
50
Total Activities
50
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 4.90 | 5.05 |
| EC50 | 16 | 5.69 | 8.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.81 |
| CHEMBL74913 | — | — | 1 | 5.96 |
| CHEMBL4072712 | — | — | 1 | 5.94 |
| CHEMBL3317515 | — | — | 1 | 5.93 |
| CHEMBL1224325 | — | — | 1 | 5.87 |
| CHEMBL4097552 | — | — | 1 | 5.84 |
| CHEMBL4060112 | — | — | 1 | 5.70 |
| CHEMBL243676 | — | — | 1 | 5.63 |
| CHEMBL272005 | — | — | 1 | 5.63 |
| CHEMBL77198 | — | — | 1 | 5.52 |
| CHEMBL242383 | RESOKAEMPFEROL | — | 1 | 5.37 |
| CHEMBL242172 | — | — | 1 | 5.29 |
| CHEMBL4464764 | — | — | 1 | 5.12 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 5.05 |
| CHEMBL294009 | FLAVONOL | — | 1 | 5.04 |
| CHEMBL379064 | ISORHAMNETIN | — | 1 | 4.95 |
| CHEMBL1801015 | — | — | 1 | 4.91 |
| CHEMBL170405 | ROBINETIN | — | 1 | 4.74 |
| CHEMBL4066636 | — | — | 1 | 4.70 |
| CHEMBL503168 | DATISCETIN | — | 1 | 4.57 |
| CHEMBL164841 | TECHTOCHRYSIN | — | 1 | - |
| CHEMBL123026 | — | — | 1 | - |
| CHEMBL289277 | EMODIN | — | 1 | - |
| CHEMBL4436500 | — | — | 1 | - |
| CHEMBL583912 | (-)-EPICATECHIN | 2.0 | 1 | - |
| CHEMBL311498 | CIANIDANOL | 4.0 | 1 | - |
| CHEMBL1883743 | — | — | 1 | - |
| CHEMBL66879 | COUMARIC ACID | — | 1 | - |
| CHEMBL1520590 | — | — | 1 | - |
| CHEMBL98521 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | EC50 | = | 1.55 | nM | 8.81 |
| CHEMBL74913 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4072712 | — | EC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL3317515 | — | EC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL1224325 | — | EC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL4097552 | — | EC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL4060112 | — | EC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL243676 | — | EC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL272005 | — | EC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL77198 | — | EC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL242383 | RESOKAEMPFEROL | EC50 | = | 4290.0 | nM | 5.37 |
| CHEMBL242172 | — | EC50 | = | 5180.0 | nM | 5.29 |
| CHEMBL4464764 | — | EC50 | = | 7560.0 | nM | 5.12 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL294009 | FLAVONOL | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL379064 | ISORHAMNETIN | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL1801015 | — | EC50 | = | 12290.0 | nM | 4.91 |
| CHEMBL170405 | ROBINETIN | EC50 | = | 18040.0 | nM | 4.74 |
| CHEMBL4066636 | — | EC50 | = | 20120.0 | nM | 4.70 |
| CHEMBL503168 | DATISCETIN | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL151 | LUTEOLIN | IC50 | < | 30000.0 | nM | - |
| CHEMBL117 | CHRYSIN | IC50 | < | 30000.0 | nM | - |
| CHEMBL16807 | 5-HYDROXYFLAVONE | IC50 | < | 30000.0 | nM | - |
| CHEMBL275638 | FLAVONE | IC50 | < | 30000.0 | nM | - |
| CHEMBL4522943 | — | IC50 | < | 30000.0 | nM | - |
| CHEMBL4448708 | — | IC50 | < | 30000.0 | nM | - |
| CHEMBL4483798 | — | IC50 | < | 30000.0 | nM | - |
| CHEMBL32571 | — | IC50 | < | 30000.0 | nM | - |
| CHEMBL399121 | HESPERETIN | IC50 | < | 30000.0 | nM | - |
| CHEMBL4591559 | — | IC50 | < | 30000.0 | nM | - |
| CHEMBL288114 | GALLIC ACID | IC50 | < | 30000.0 | nM | - |
| CHEMBL284616 | CHLOROGENIC ACID | IC50 | < | 30000.0 | nM | - |
| CHEMBL32749 | FERULATE | IC50 | < | 30000.0 | nM | - |
| CHEMBL95769 | — | IC50 | < | 30000.0 | nM | - |
| CHEMBL233295 | ISOFERULIC ACID | IC50 | < | 30000.0 | nM | - |
| CHEMBL145 | CAFFEIC ACID | IC50 | < | 30000.0 | nM | - |
| CHEMBL275391 | CHRYSIN DIMETHYL ETHER | IC50 | < | 30000.0 | nM | - |
| CHEMBL214321 | CHRYSOERIOL | IC50 | < | 30000.0 | nM | - |
| CHEMBL4459773 | — | IC50 | < | 30000.0 | nM | - |
| CHEMBL52564 | O-COUMARIC ACID | IC50 | < | 30000.0 | nM | - |
| CHEMBL98521 | — | IC50 | < | 30000.0 | nM | - |
| CHEMBL1520590 | — | IC50 | < | 30000.0 | nM | - |
| CHEMBL66879 | COUMARIC ACID | IC50 | < | 30000.0 | nM | - |
| CHEMBL1883743 | — | IC50 | < | 30000.0 | nM | - |
| CHEMBL311498 | CIANIDANOL | IC50 | < | 30000.0 | nM | - |
| CHEMBL583912 | (-)-EPICATECHIN | IC50 | < | 30000.0 | nM | - |
| CHEMBL4436500 | — | IC50 | < | 30000.0 | nM | - |
| CHEMBL289277 | EMODIN | IC50 | < | 30000.0 | nM | - |
| CHEMBL123026 | — | IC50 | < | 30000.0 | nM | - |
| CHEMBL164841 | TECHTOCHRYSIN | IC50 | < | 30000.0 | nM | - |