Compound Detail
CHEMBL242383
RESOKAEMPFEROL Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL242383 |
| Name | RESOKAEMPFEROL |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OBWHQJYOOCRPST-UHFFFAOYSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
17
Publications
0
Known Names
Molecular Properties
270.2
MW (Da)
2.58
ALogP
5
HBA
3
HBD
90.9
PSA (Ų)
0.63
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.56
EC50 1 meas. best 5.37
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma brucei brucei CHEMBL612851 | EC50 | 5.37 | 5.37 | 4290.0 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C CHEMBL3762 | IC50 | 4.56 | 4.56 | 27500.0 | 1 |
| CWR22R CHEMBL612657 | IC50 | 4.52 | 4.52 | 30200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Trypanosoma brucei brucei | EC50 | = | 4290.0 | nM | 5.37 | Antitrypanosomal activity against Trypanosoma brucei brucei Lister 427 bloodstre... | 27411733 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | IC50 | = | 27500.0 | nM | 4.56 | Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in ra... | - |
| CWR22R | IC50 | = | 30200.0 | nM | 4.52 | Antiproliferative activity against human 22Rv1 cells incubated up to 144 hrs by ... | 22789812 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22789812 | 10.1016/j.ejmech.2012.06.031 | CWR22R | 5 |
| 27411733 | 10.1021/acs.jmedchem.6b00698 | Unchecked | 4 |
| 27411733 | 10.1021/acs.jmedchem.6b00698 | Trypanosoma brucei brucei | 4 |
| 17166721 | 10.1016/j.bmc.2006.11.037 | NON-PROTEIN TARGET | 3 |
| 17166721 | 10.1016/j.bmc.2006.11.037 | Radical scavenging activity | 2 |
| 19931462 | 10.1016/j.bmc.2009.10.063 | Unchecked | 2 |
| 32364726 | 10.1021/acs.jnatprod.0c00014 | Fructose-1,6-bisphosphatase 1 | 1 |
| 27411733 | 10.1021/acs.jmedchem.6b00698 | Cytochrome P450 1A2 | 1 |
| 27411733 | 10.1021/acs.jmedchem.6b00698 | THP-1 | 1 |
| 27411733 | 10.1021/acs.jmedchem.6b00698 | WI-38 | 1 |
| 27411733 | 10.1021/acs.jmedchem.6b00698 | A549 | 1 |
| 27411733 | 10.1021/acs.jmedchem.6b00698 | 786-0 | 1 |
| 27411733 | 10.1021/acs.jmedchem.6b00698 | Thymidylate synthase | 1 |
| 27411733 | 10.1021/acs.jmedchem.6b00698 | Dihydrofolate reductase | 1 |
| 24630560 | 10.1016/j.bmcl.2014.02.039 | Aromatase | 1 |
| 8350096 | 10.1021/np50096a027 | Unchecked | 1 |
| 17637507 | 10.1016/j.bmc.2007.06.025 | Serine/threonine-protein kinase pim-1 | 1 |
Data from ChEMBL 36 via Core Engine