Assay Detail
Binding
CHEMBL4679656
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence by MST based assay
40
Total Activities
24
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Sweet and Blind Spots in E3 Ligase Ligand Space Revealed by a Thermophoresis-Based Assay.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.49 | 4.81 |
| Ki | 16 | 4.82 | 5.33 |
| Activity | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3137312 | DASABUVIR | 4.0 | 2 | 5.33 |
| CHEMBL3989927 | IBERDOMIDE | 3.0 | 2 | 5.31 |
| CHEMBL275661 | SUCCINIMIDE | -1.0 | 2 | 5.09 |
| CHEMBL43452 | POMALIDOMIDE | 4.0 | 2 | 5.00 |
| CHEMBL848 | LENALIDOMIDE | 4.0 | 2 | 4.79 |
| CHEMBL3989934 | AVADOMIDE | 2.0 | 2 | 4.78 |
| CHEMBL4797970 | — | — | 2 | 4.51 |
| CHEMBL4759876 | — | — | 2 | 4.39 |
| CHEMBL4758352 | — | — | 2 | 4.17 |
| CHEMBL100259 | URIDINE | 3.0 | 2 | - |
| CHEMBL1259059 | SOFOSBUVIR | 4.0 | 1 | - |
| CHEMBL566 | URACIL | 3.0 | 2 | - |
| CHEMBL63 | ROLIPRAM | 2.0 | 2 | - |
| CHEMBL504 | DIMETHYL SULFOXIDE | 4.0 | 2 | - |
| CHEMBL214393 | — | — | 1 | - |
| CHEMBL122334 | HYDANTOIN | — | 2 | - |
| CHEMBL30446 | — | — | 1 | - |
| CHEMBL3707254 | FURAZIDIN | -1.0 | 1 | - |
| CHEMBL4758543 | — | — | 1 | - |
| CHEMBL315108 | AZUMOLENE | 2.0 | 1 | - |
| CHEMBL572 | NITROFURANTOIN | 4.0 | 1 | - |
| CHEMBL4785425 | — | — | 1 | - |
| CHEMBL4756680 | — | — | 2 | - |
| CHEMBL1958109 | THIOHYDANTOIN | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3137312 | DASABUVIR | Ki | = | 4710.0 | nM | 5.33 |
| CHEMBL3989927 | IBERDOMIDE | Ki | = | 4940.0 | nM | 5.31 |
| CHEMBL275661 | SUCCINIMIDE | Ki | = | 8190.0 | nM | 5.09 |
| CHEMBL43452 | POMALIDOMIDE | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL3137312 | DASABUVIR | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL3989927 | IBERDOMIDE | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL848 | LENALIDOMIDE | Ki | = | 16300.0 | nM | 4.79 |
| CHEMBL3989934 | AVADOMIDE | Ki | = | 16700.0 | nM | 4.78 |
| CHEMBL275661 | SUCCINIMIDE | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL43452 | POMALIDOMIDE | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL4797970 | — | Ki | = | 30800.0 | nM | 4.51 |
| CHEMBL848 | LENALIDOMIDE | IC50 | = | 37800.0 | nM | 4.42 |
| CHEMBL3989934 | AVADOMIDE | IC50 | = | 38700.0 | nM | 4.41 |
| CHEMBL4759876 | — | Ki | = | 40700.0 | nM | 4.39 |
| CHEMBL4797970 | — | IC50 | = | 65700.0 | nM | 4.18 |
| CHEMBL4758352 | — | Ki | = | 67800.0 | nM | 4.17 |
| CHEMBL4759876 | — | IC50 | = | 84800.0 | nM | 4.07 |
| CHEMBL4756680 | — | Ki | = | 229000.0 | nM | - |
| CHEMBL4785425 | — | Activity | - | — | - | |
| CHEMBL572 | NITROFURANTOIN | Activity | - | — | - | |
| CHEMBL315108 | AZUMOLENE | Activity | - | — | - | |
| CHEMBL4758543 | — | Activity | - | — | - | |
| CHEMBL3707254 | FURAZIDIN | IC50 | > | 1000000.0 | nM | - |
| CHEMBL100259 | URIDINE | Ki | = | 390000.0 | nM | - |
| CHEMBL1958109 | THIOHYDANTOIN | Ki | = | 169000.0 | nM | - |
| CHEMBL1958109 | THIOHYDANTOIN | IC50 | = | 332000.0 | nM | - |
| CHEMBL4758352 | — | IC50 | = | 137000.0 | nM | - |
| CHEMBL30446 | — | IC50 | > | 5000000.0 | nM | - |
| CHEMBL4756680 | — | IC50 | = | 447000.0 | nM | - |
| CHEMBL122334 | HYDANTOIN | IC50 | = | 421000.0 | nM | - |
| CHEMBL214393 | — | IC50 | > | 5000000.0 | nM | - |
| CHEMBL504 | DIMETHYL SULFOXIDE | Ki | = | 137000.0 | nM | - |
| CHEMBL504 | DIMETHYL SULFOXIDE | IC50 | = | 264000.0 | nM | - |
| CHEMBL63 | ROLIPRAM | IC50 | = | 202000.0 | nM | - |
| CHEMBL63 | ROLIPRAM | Ki | = | 102000.0 | nM | - |
| CHEMBL566 | URACIL | IC50 | = | 415000.0 | nM | - |
| CHEMBL566 | URACIL | Ki | = | 212000.0 | nM | - |
| CHEMBL1259059 | SOFOSBUVIR | IC50 | > | 1000000.0 | nM | - |
| CHEMBL100259 | URIDINE | IC50 | = | 757000.0 | nM | - |
| CHEMBL122334 | HYDANTOIN | Ki | = | 216000.0 | nM | - |