Assay Detail
Binding
CHEMBL4700551
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human alpha-synuclein filament formation expressed in Escherichia coli BL21(DE3) cells incubated for 72 hrs by thioflavin S based fluorescence assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Toward the discovery and development of effective modulators of α-synuclein amyloid aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.94 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL264938 | GALLOCATECHIN GALLATE | — | 1 | 5.44 |
| CHEMBL38714 | PROCYANIDIN B2 | — | 1 | 5.37 |
| CHEMBL590878 | DELPHINIDIN CHLORIDE | — | 1 | 5.19 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.15 |
| CHEMBL504937 | PROCYANIDIN B1 | — | 1 | 5.14 |
| CHEMBL286494 | HYPERICIN | 3.0 | 1 | 5.12 |
| CHEMBL8260 | BAICALEIN | 2.0 | 1 | 5.09 |
| CHEMBL125743 | GALLOCATECHIN | — | 1 | 5.05 |
| CHEMBL36327 | EPICATECHIN GALLATE | — | 1 | 5.01 |
| CHEMBL511367 | CYANIDIN CHLORIDE | — | 1 | 4.99 |
| CHEMBL47386 | EPIGALLOCATECHIN | — | 1 | 4.97 |
| CHEMBL66953 | PURPUROGALLIN | — | 1 | 4.89 |
| CHEMBL164 | MYRICETIN | — | 1 | 4.88 |
| CHEMBL4789704 | — | — | 1 | 4.83 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.70 |
| CHEMBL129451 | (-)-CATECHINGALLATE | — | 1 | 4.67 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 4.55 |
| CHEMBL583912 | (-)-EPICATECHIN | 2.0 | 1 | 4.52 |
| CHEMBL374478 | RIFAMPIN | 4.0 | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL264938 | GALLOCATECHIN GALLATE | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL38714 | PROCYANIDIN B2 | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL590878 | DELPHINIDIN CHLORIDE | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL59 | DOPAMINE | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL504937 | PROCYANIDIN B1 | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL286494 | HYPERICIN | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL8260 | BAICALEIN | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL125743 | GALLOCATECHIN | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL36327 | EPICATECHIN GALLATE | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL511367 | CYANIDIN CHLORIDE | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL47386 | EPIGALLOCATECHIN | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL66953 | PURPUROGALLIN | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL164 | MYRICETIN | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL4789704 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL50 | QUERCETIN | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL129451 | (-)-CATECHINGALLATE | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL583912 | (-)-EPICATECHIN | IC50 | = | 29900.0 | nM | 4.52 |
| CHEMBL374478 | RIFAMPIN | IC50 | = | 46200.0 | nM | 4.33 |