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Compound Detail

CHEMBL504937

PROCYANIDIN B1
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Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@H](O)[C@H]2c1c(O)cc(O)c2c1O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2

Basic Information

ChEMBL ID CHEMBL504937
Name PROCYANIDIN B1
Phase Preclinical
Structure Type MOL
InChI Key XFZJEEAOWLFHDH-UKWJTHFESA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names

Molecular Properties

578.5
MW (Da)
3.00
ALogP
12
HBA
10
HBD
220.8
PSA (Ų)
0.16
QED
3
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C30H26O12
MW 578.53
Aromatic Rings 4
Heavy Atoms 42
NP-Likeness 1.93

Activity Summary

IC50 3 meas. best 5.14

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Alpha-synuclein
CHEMBL6152
IC50 5.14 5.14 7300.0 1
Molecular identity unknown
CHEMBL612546
IC50 4.5 4.32 31300.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
24749980 10.1021/np400781y Escherichia coli 3
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
10425115 10.1021/np980481o Molecular identity unknown 2
10425115 10.1021/np980481o Escherichia coli 2
10425115 10.1021/np980481o Pseudomonas aeruginosa 2
10425115 10.1021/np980481o Salmonella paratyphi 2
10425115 10.1021/np980481o Enterobacter cloacae 2
10425115 10.1021/np980481o Mycolicibacterium fortuitum 2
10425115 10.1021/np980481o Staphylococcus aureus 2
10425115 10.1021/np980481o Candida albicans 2
19944611 10.1016/j.bmc.2009.11.015 No relevant target 2
24245939 10.1021/np400518k HT-22 2
10425115 10.1021/np980481o NON-PROTEIN TARGET 1
30743095 10.1016/j.ejmech.2019.01.045 Alpha-synuclein 1
31433178 10.1021/acs.jnatprod.8b00953 Dentine 1
31433178 10.1021/acs.jnatprod.8b00953 ADMET 1
31195169 10.1016/j.ejmech.2019.05.078 Unchecked 1
- 10.21203/rs.3.rs-23951/v1 SARS-CoV-2 1
19944611 10.1016/j.bmc.2009.11.015 NON-PROTEIN TARGET 1
10425115 10.1021/np980481o MT4 1

Data from ChEMBL 36 via Core Engine