Assay Detail
Binding
CHEMBL4705571
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Inhibition of F protein in Respiratory syncytial virus A2 infected in HepG2 cells assessed as reduction in virus-induced cytopathic effect incubated for 4 days by XTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human respiratory syncytial virus A2 |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Fusion glycoprotein F0 (CHEMBL3856166) ↗| Type | SINGLE PROTEIN |
| Organism | Human respiratory syncytial virus A (strain A2) |
Publication
Discovery of a potent dual inhibitor of wild-type and mutant respiratory syncytial virus fusion proteins through the modulation of atropisomer interconversion properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 8.69 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4740044 | — | — | 1 | 9.57 |
| CHEMBL4750881 | — | — | 1 | 9.48 |
| CHEMBL4747540 | — | — | 1 | 9.33 |
| CHEMBL4755451 | — | — | 1 | 9.19 |
| CHEMBL4746199 | — | — | 1 | 9.13 |
| CHEMBL4765002 | — | — | 1 | 9.11 |
| CHEMBL4747375 | — | — | 1 | 9.09 |
| CHEMBL4747256 | — | — | 1 | 9.06 |
| CHEMBL4752524 | — | — | 1 | 8.96 |
| CHEMBL4751254 | — | — | 1 | 8.96 |
| CHEMBL4753413 | — | — | 1 | 8.85 |
| CHEMBL4752460 | — | — | 1 | 8.85 |
| CHEMBL4757367 | — | — | 1 | 8.77 |
| CHEMBL4640616 | — | — | 1 | 8.70 |
| CHEMBL4779491 | — | — | 1 | 8.68 |
| CHEMBL4742185 | — | — | 1 | 8.60 |
| CHEMBL4741045 | — | — | 1 | 8.57 |
| CHEMBL4761881 | — | — | 1 | 8.34 |
| CHEMBL4758615 | — | — | 1 | 8.15 |
| CHEMBL4756466 | — | — | 1 | 7.77 |
| CHEMBL4752948 | — | — | 1 | 7.77 |
| CHEMBL4782630 | — | — | 1 | 7.68 |
| CHEMBL4746117 | — | — | 1 | 7.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4740044 | — | EC50 | = | 0.27 | nM | 9.57 |
| CHEMBL4750881 | — | EC50 | = | 0.33 | nM | 9.48 |
| CHEMBL4747540 | — | EC50 | = | 0.47 | nM | 9.33 |
| CHEMBL4755451 | — | EC50 | = | 0.64 | nM | 9.19 |
| CHEMBL4746199 | — | EC50 | = | 0.74 | nM | 9.13 |
| CHEMBL4765002 | — | EC50 | = | 0.77 | nM | 9.11 |
| CHEMBL4747375 | — | EC50 | = | 0.81 | nM | 9.09 |
| CHEMBL4747256 | — | EC50 | = | 0.87 | nM | 9.06 |
| CHEMBL4752524 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4751254 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4753413 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4752460 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4757367 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4640616 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4779491 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4742185 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4741045 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4761881 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4758615 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4756466 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4752948 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4782630 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4746117 | — | EC50 | = | 54.0 | nM | 7.27 |