Assay Detail
Functional
CHEMBL4712759
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Antitrypanosomal activity against Trypanosoma cruzi infected in human MRC-5 SV2 cells
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | MRC-5 SV2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of a collection of purine-like C-nucleosides as antikinetoplastid agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.73 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4764464 | — | — | 1 | 6.64 |
| CHEMBL4790411 | — | — | 1 | 6.47 |
| CHEMBL4787773 | — | — | 1 | 6.34 |
| CHEMBL4634483 | — | — | 1 | 6.27 |
| CHEMBL4742019 | — | — | 1 | 6.22 |
| CHEMBL4788848 | — | — | 1 | 6.21 |
| CHEMBL4744476 | — | — | 1 | 6.11 |
| CHEMBL4751562 | — | — | 1 | 5.98 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 5.70 |
| CHEMBL4764594 | — | — | 1 | 5.61 |
| CHEMBL4758694 | — | — | 1 | 5.42 |
| CHEMBL4777562 | — | — | 1 | 5.12 |
| CHEMBL4794928 | — | — | 1 | 5.00 |
| CHEMBL4751346 | — | — | 1 | 4.51 |
| CHEMBL4755821 | — | — | 1 | 4.41 |
| CHEMBL4758898 | — | — | 1 | - |
| CHEMBL4783188 | — | — | 1 | - |
| CHEMBL2016757 | GS-441524 | 1.0 | 1 | - |
| CHEMBL4753867 | — | — | 1 | - |
| CHEMBL4793136 | — | — | 1 | - |
| CHEMBL4079082 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4764464 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4790411 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4787773 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4634483 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4742019 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4788848 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4744476 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4751562 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL4764594 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL4758694 | — | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL4777562 | — | IC50 | = | 7670.0 | nM | 5.12 |
| CHEMBL4794928 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL4751346 | — | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL4755821 | — | IC50 | = | 39300.0 | nM | 4.41 |
| CHEMBL4758898 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4783188 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2016757 | GS-441524 | IC50 | > | 64000.0 | nM | - |
| CHEMBL4753867 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4793136 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4079082 | — | IC50 | < | 250.0 | nM | - |