Assay Detail
Functional
CHEMBL4815968
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma cruzi Tulahuen CL2 infected in human MRC5 cells assessed as inhibition of parasite growth incubated for 7 days by chlorophenol red-fl-D-galactopyranoside based spectrophotometric analysis
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 3'-fluorinated 7-deazapurine nucleosides as antikinetoplastid agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 40 | 5.89 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4849239 | — | — | 1 | 7.41 |
| CHEMBL4871173 | — | — | 1 | 7.40 |
| CHEMBL4856247 | — | — | 1 | 7.39 |
| CHEMBL4852417 | — | — | 1 | 7.15 |
| CHEMBL4861248 | — | — | 1 | 6.77 |
| CHEMBL4858295 | — | — | 1 | 6.66 |
| CHEMBL4870078 | — | — | 1 | 6.60 |
| CHEMBL4879131 | — | — | 1 | 6.38 |
| CHEMBL72928 | — | — | 1 | 6.26 |
| CHEMBL4854535 | — | — | 1 | 6.19 |
| CHEMBL4855327 | — | — | 1 | 6.13 |
| CHEMBL4873064 | — | — | 1 | 6.12 |
| CHEMBL4849638 | — | — | 1 | 5.84 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 5.70 |
| CHEMBL4860880 | — | — | 1 | 5.50 |
| CHEMBL4869277 | — | — | 1 | 5.37 |
| CHEMBL4862263 | — | — | 1 | 5.15 |
| CHEMBL4859430 | — | — | 1 | 5.13 |
| CHEMBL4867618 | — | — | 1 | 5.07 |
| CHEMBL4846004 | — | — | 1 | 5.04 |
| CHEMBL4866903 | — | — | 1 | 5.04 |
| CHEMBL4857373 | — | — | 1 | 5.01 |
| CHEMBL4853463 | — | — | 1 | 4.88 |
| CHEMBL4863184 | — | — | 1 | 4.52 |
| CHEMBL420751 | — | — | 1 | 4.46 |
| CHEMBL4856223 | — | — | 1 | - |
| CHEMBL4853123 | — | — | 1 | - |
| CHEMBL4871274 | — | — | 1 | - |
| CHEMBL4878319 | — | — | 1 | - |
| CHEMBL4868788 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4849239 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4871173 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4856247 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4852417 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4861248 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4858295 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4870078 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4879131 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL72928 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4854535 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4855327 | — | EC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4873064 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4849638 | — | EC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL110 | BENZNIDAZOLE | EC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL4860880 | — | EC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL4869277 | — | EC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL4862263 | — | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4859430 | — | EC50 | = | 7460.0 | nM | 5.13 |
| CHEMBL4867618 | — | EC50 | = | 8610.0 | nM | 5.07 |
| CHEMBL4866903 | — | EC50 | = | 9140.0 | nM | 5.04 |
| CHEMBL4846004 | — | EC50 | = | 9090.0 | nM | 5.04 |
| CHEMBL4857373 | — | EC50 | = | 9660.0 | nM | 5.01 |
| CHEMBL4853463 | — | EC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL4863184 | — | EC50 | = | 30100.0 | nM | 4.52 |
| CHEMBL420751 | — | EC50 | = | 34600.0 | nM | 4.46 |
| CHEMBL4865014 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4874598 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4852610 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4867811 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4878243 | — | EC50 | < | 210.0 | nM | - |
| CHEMBL4871965 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4849363 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4853520 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4854963 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4872128 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4868788 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4878319 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4871274 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4853123 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4856223 | — | EC50 | > | 64000.0 | nM | - |