Assay Detail
Functional
CHEMBL4840640
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Antitrypanosomal activity against Trypanosoma cruzi trypomastigotes assessed as inhibition of cellular invasion incubated for 6 hrs in high-glucose DMEM medium followed by compound washout further infected in BSR cells measured after 72 hrs by fluorescence based analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | BSR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of Mannich base-type derivatives containing imidazole and benzimidazole as lead compounds for drug discovery in Chagas Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.78 | 5.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4856014 | — | — | 1 | 5.04 |
| CHEMBL4867967 | — | — | 1 | 4.78 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 4.65 |
| CHEMBL4853502 | — | — | 1 | 4.64 |
| CHEMBL4853501 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4856014 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4867967 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL4853502 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4853501 | — | IC50 | - | — | - |