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Assay Detail

CHEMBL4841972

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]propionyl-pNPY from human neuropeptide Y Y5 receptor in human HEC-1B cells measured after 90 mins by scintillation counting analysis
42
Total Activities
21
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEC-1B cell line
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Neuropeptide Y receptor type 5 (CHEMBL4561)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

N-Terminus to Arginine Side-Chain Cyclization of Linear Peptidic Neuropeptide Y Y<sub>4</sub> Receptor Ligands Results in Picomolar Binding Constants.
Konieczny A, Conrad M, Ertl FJ, Gleixner J, Gattor AO, Grätz L, Schmidt MF, Neu E, Horn AHC, Wifling D, Gmeiner P, Clark T, Sticht H, Keller M.
J Med Chem (2021) 64 : 16746 -16769
PubMed 34748345 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 39 6.84 7.77
pKi 3 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4540843 PANCREATIC POLYPEPTIDE 2.0 2 7.77
CHEMBL4877802 2 5.00
CHEMBL4633593 2 -
CHEMBL4852354 2 -
CHEMBL4866955 2 -
CHEMBL4858915 2 -
CHEMBL4865048 2 -
CHEMBL4873376 2 -
CHEMBL4866086 2 -
CHEMBL4862140 2 -
CHEMBL4870168 2 -
CHEMBL4856311 2 -
CHEMBL4863955 2 -
CHEMBL4852799 2 -
CHEMBL4860290 2 -
CHEMBL4857577 2 -
CHEMBL4874850 2 -
CHEMBL4874445 2 -
CHEMBL4868787 2 -
CHEMBL4861544 2 -
CHEMBL4848958 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4540843 PANCREATIC POLYPEPTIDE Ki = 17.0 nM 7.77
CHEMBL4540843 PANCREATIC POLYPEPTIDE Ki = 17.78 nM 7.75
CHEMBL4877802 Ki = 10000.0 nM 5.00
CHEMBL4633593 Ki > 3162.28 nM -
CHEMBL4868787 pKi - -
CHEMBL4852354 Ki > 3162.28 nM -
CHEMBL4866955 pKi - -
CHEMBL4858915 Ki > 3162.28 nM -
CHEMBL4865048 Ki > 10000.0 nM -
CHEMBL4873376 Ki > 1000.0 nM -
CHEMBL4877802 Ki > 10000.0 nM -
CHEMBL4866086 Ki > 1000000.0 nM -
CHEMBL4862140 Ki > 10000.0 nM -
CHEMBL4861544 pKi - -
CHEMBL4870168 Ki > 10000.0 nM -
CHEMBL4856311 Ki > 1000.0 nM -
CHEMBL4863955 Ki > 10000.0 nM -
CHEMBL4852799 Ki > 10000.0 nM -
CHEMBL4860290 Ki > 10000.0 nM -
CHEMBL4857577 Ki > 1000.0 nM -
CHEMBL4874850 Ki > 3162.28 nM -
CHEMBL4874445 Ki > 10000.0 nM -
CHEMBL4868787 Ki - -
CHEMBL4862140 Ki > 10000.0 nM -
CHEMBL4861544 Ki - -
CHEMBL4633593 Ki > 3000.0 nM -
CHEMBL4852354 Ki > 3000.0 nM -
CHEMBL4866955 Ki - -
CHEMBL4858915 Ki > 3000.0 nM -
CHEMBL4865048 Ki > 10.0 nM -
CHEMBL4873376 Ki > 3000.0 nM -
CHEMBL4866086 Ki > 10000.0 nM -
CHEMBL4848958 Ki > 3162.28 nM -
CHEMBL4848958 Ki > 3000.0 nM -
CHEMBL4870168 Ki > 10.0 nM -
CHEMBL4856311 Ki > 3000.0 nM -
CHEMBL4863955 Ki > 10000.0 nM -
CHEMBL4852799 Ki > 10000.0 nM -
CHEMBL4860290 Ki > 10000.0 nM -
CHEMBL4857577 Ki > 3000.0 nM -
CHEMBL4874850 Ki > 3000.0 nM -
CHEMBL4874445 Ki > 10000.0 nM -